Cardiac structure and function in well-healed burn survivors

T. Jake Samuel, Michael D. Nelson, Aida Nasirian, Manall Jaffery, Gilbert Moralez, Steven A. Romero, Matthew N. Cramer, Mu Huang, Ken Kouda, Michinari Hieda, Satyam Sarma, Craig G. Crandall

Research output: Contribution to journalArticle

Abstract

Long-Term burn survivors have reduced aerobic capacity, placing them at increased risk for cardiovascular disease, morbidity, and mortality. However, the exact mechanism contributing to a reduced aerobic capacity remains incompletely understood, but may be related to adverse cardiovascular remodeling. Therefore, it was hypothesized that well-healed burn survivors would exhibit adverse left ventricular (LV) remodeling and impaired LV function. To test this hypothesis, 22 well-healed moderately burned individuals (age: 41 ± 14 years; BMI: 27.7 ± 5.4 kg/m 2; male/female: 12/10; extent of burn: 37 ± 12 %BSA), 11 well-healed severely burned individuals (age: 43 ± 12 years; BMI: 29.5 ± 5.8 kg/m 2; male/female: 8/3; extent of burn: 73 ± 11 %BSA), and 12 healthy, age-matched controls (age: 34 ± 9 years; BMI: 28.6 ± 5.2 kg/m 2; male/female: 5/7) were enrolled in the study. All subjects were sedentary, performing less than 30 minutes of aerobic exercise per day, 3 days per week. LV morphology and function were assessed via cardiac magnetic resonance imaging. In contrast to the hypothesis, neither the presence nor severity of burn injury adversely affected LV morphology or function, when compared with equally sedentary nonburned controls. However, of note, LV mass of all three groups was in the lowest 5th percentile compared with normative values. Finally, group differences in LV morphology were largely explained by differences in aerobic capacity. Taken together, these data suggest a prior burn injury itself does not result in pathological remodeling of the LV and support a role for aerobic exercise training to improve cardiac function.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalJournal of Burn Care and Research
Volume40
Issue number2
DOIs
Publication statusPublished - Feb 20 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Emergency Medicine
  • Rehabilitation

Fingerprint Dive into the research topics of 'Cardiac structure and function in well-healed burn survivors'. Together they form a unique fingerprint.

  • Cite this

    Samuel, T. J., Nelson, M. D., Nasirian, A., Jaffery, M., Moralez, G., Romero, S. A., Cramer, M. N., Huang, M., Kouda, K., Hieda, M., Sarma, S., & Crandall, C. G. (2019). Cardiac structure and function in well-healed burn survivors. Journal of Burn Care and Research, 40(2), 235-241. https://doi.org/10.1093/jbcr/irz008