Cardiovascular and metabolic diseases comorbid with psoriasis: Beyond the skin

Masutaka Furue, Gaku Tsuji, Takahito Chiba, Takafumi Kadono

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

A close association of systemic inflammation with cardiovascular diseases and metabolic syndrome is recently a popular topic in medicine. Psoriasis is a chronic inflammatory skin disease with a prevalence of approximately 0.1-0.5% in Asians. It is characterized by widespread scaly erythematous macules that cause significant physical and psychological burdens for the affected individuals. The accelerated inflammation driven by the TNF-α/IL-23/IL-17A axis is now known to be the major mechanism in the development of psoriasis. Psoriasis is not a mere skin disease; it is significantly associated with cardiovascular diseases and metabolic syndrome, which suggests that the chronic skin inflammation extends the systemic inflammation beyond the skin. In this article, we review the epidemiological and pathological aspects of psoriasis and its comorbidities.

Original languageEnglish
Pages (from-to)1613-1619
Number of pages7
JournalInternal Medicine
Volume56
Issue number13
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Metabolic Diseases
Psoriasis
Cardiovascular Diseases
Inflammation
Skin
Skin Diseases
Interleukin-23
Interleukin-17
Comorbidity
Medicine
Psychology

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Cardiovascular and metabolic diseases comorbid with psoriasis : Beyond the skin. / Furue, Masutaka; Tsuji, Gaku; Chiba, Takahito; Kadono, Takafumi.

In: Internal Medicine, Vol. 56, No. 13, 01.01.2017, p. 1613-1619.

Research output: Contribution to journalReview article

Furue, Masutaka ; Tsuji, Gaku ; Chiba, Takahito ; Kadono, Takafumi. / Cardiovascular and metabolic diseases comorbid with psoriasis : Beyond the skin. In: Internal Medicine. 2017 ; Vol. 56, No. 13. pp. 1613-1619.
@article{c2f6817c3f61431398497eb4537ac1a3,
title = "Cardiovascular and metabolic diseases comorbid with psoriasis: Beyond the skin",
abstract = "A close association of systemic inflammation with cardiovascular diseases and metabolic syndrome is recently a popular topic in medicine. Psoriasis is a chronic inflammatory skin disease with a prevalence of approximately 0.1-0.5{\%} in Asians. It is characterized by widespread scaly erythematous macules that cause significant physical and psychological burdens for the affected individuals. The accelerated inflammation driven by the TNF-α/IL-23/IL-17A axis is now known to be the major mechanism in the development of psoriasis. Psoriasis is not a mere skin disease; it is significantly associated with cardiovascular diseases and metabolic syndrome, which suggests that the chronic skin inflammation extends the systemic inflammation beyond the skin. In this article, we review the epidemiological and pathological aspects of psoriasis and its comorbidities.",
author = "Masutaka Furue and Gaku Tsuji and Takahito Chiba and Takafumi Kadono",
year = "2017",
month = "1",
day = "1",
doi = "10.2169/internalmedicine.56.8209",
language = "English",
volume = "56",
pages = "1613--1619",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "13",

}

TY - JOUR

T1 - Cardiovascular and metabolic diseases comorbid with psoriasis

T2 - Beyond the skin

AU - Furue, Masutaka

AU - Tsuji, Gaku

AU - Chiba, Takahito

AU - Kadono, Takafumi

PY - 2017/1/1

Y1 - 2017/1/1

N2 - A close association of systemic inflammation with cardiovascular diseases and metabolic syndrome is recently a popular topic in medicine. Psoriasis is a chronic inflammatory skin disease with a prevalence of approximately 0.1-0.5% in Asians. It is characterized by widespread scaly erythematous macules that cause significant physical and psychological burdens for the affected individuals. The accelerated inflammation driven by the TNF-α/IL-23/IL-17A axis is now known to be the major mechanism in the development of psoriasis. Psoriasis is not a mere skin disease; it is significantly associated with cardiovascular diseases and metabolic syndrome, which suggests that the chronic skin inflammation extends the systemic inflammation beyond the skin. In this article, we review the epidemiological and pathological aspects of psoriasis and its comorbidities.

AB - A close association of systemic inflammation with cardiovascular diseases and metabolic syndrome is recently a popular topic in medicine. Psoriasis is a chronic inflammatory skin disease with a prevalence of approximately 0.1-0.5% in Asians. It is characterized by widespread scaly erythematous macules that cause significant physical and psychological burdens for the affected individuals. The accelerated inflammation driven by the TNF-α/IL-23/IL-17A axis is now known to be the major mechanism in the development of psoriasis. Psoriasis is not a mere skin disease; it is significantly associated with cardiovascular diseases and metabolic syndrome, which suggests that the chronic skin inflammation extends the systemic inflammation beyond the skin. In this article, we review the epidemiological and pathological aspects of psoriasis and its comorbidities.

UR - http://www.scopus.com/inward/record.url?scp=85021725237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021725237&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.56.8209

DO - 10.2169/internalmedicine.56.8209

M3 - Review article

C2 - 28674347

AN - SCOPUS:85021725237

VL - 56

SP - 1613

EP - 1619

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 13

ER -