Cardiovascular protective action of Rho-kinase inhibitors

Yoshitaka Hirooka

    Research output: Contribution to journalReview articlepeer-review


    The Rho/Rho-kinase pathway plays an important role in pathophysiology and formation of hypertensive vascular diseases. This pathway contributes to both increased vascular resistance and atherosclerotic changes. The latter includes inflammatory and proliferative changes. In patients with hypertension, inhibition of Rho-kinase has been shown to decrease the increased vascular resistance. Therefore, Rho-kinase will be a new therapeutic target for hypertension and hypertensive vascular diseases. Thus, Rho-kinase inhibitors may have a cardioprotective action.

    Original languageEnglish
    Pages (from-to)161-171
    Number of pages11
    JournalNippon rinsho. Japanese journal of clinical medicine
    Issue number1
    Publication statusPublished - Jan 2004

    All Science Journal Classification (ASJC) codes

    • Medicine(all)


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