Cardiovascular protective action of Rho-kinase inhibitors

Yoshitaka Hirooka

Research output: Contribution to journalReview article


The Rho/Rho-kinase pathway plays an important role in pathophysiology and formation of hypertensive vascular diseases. This pathway contributes to both increased vascular resistance and atherosclerotic changes. The latter includes inflammatory and proliferative changes. In patients with hypertension, inhibition of Rho-kinase has been shown to decrease the increased vascular resistance. Therefore, Rho-kinase will be a new therapeutic target for hypertension and hypertensive vascular diseases. Thus, Rho-kinase inhibitors may have a cardioprotective action.

Original languageEnglish
Pages (from-to)161-171
Number of pages11
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number1
Publication statusPublished - Jan 1 2004


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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