Carnosine activates the CREB pathway in Caco-2 cells

Kaoru Fujii, Kayoko Abe, Keishi Kadooka, Takashi Matsumoto, Yoshinori Katakura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Imidazole dipeptide, carnosine, is a versatile compound composed of β-Ala and l-His. A recent study showed that carnosine might benefit the treatment of Alzheimer’s disease and the maintenance of cognitive function. Based on the observation that carnosine is immediately degraded by serum carnosinase, we hypothesized that carnosine improves brain function by promoting brain-gut interaction. This study sought to present possible mechanisms regulating carnosine-induced activation of brain-gut interaction. We had previously found that carnosine augmented the expression of BDNF in human colorectal cancer cells, thus we became interested in cAMP-responsive element binding protein (CREB), which is a dominant regulator of BDNF transcription. We found that carnosine activates CREB and CREB-related pathways by activating Ca2+-related pathways. Our findings suggest that carnosine augments the expression of CREB-regulated genes in the intestine; this augmentation contributes to the carnosine-induced activation of brain-gut interaction.

Original languageEnglish
Pages (from-to)523-527
Number of pages5
JournalCytotechnology
Volume69
Issue number3
DOIs
Publication statusPublished - Jun 1 2017

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Carnosine
Caco-2 Cells
Brain
Carrier Proteins
Chemical activation
Transcription
Brain-Derived Neurotrophic Factor
Genes
Cells
Dipeptides
Cognition
Intestines
Colorectal Neoplasms
Alzheimer Disease
Maintenance

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Clinical Biochemistry
  • Cell Biology

Cite this

Carnosine activates the CREB pathway in Caco-2 cells. / Fujii, Kaoru; Abe, Kayoko; Kadooka, Keishi; Matsumoto, Takashi; Katakura, Yoshinori.

In: Cytotechnology, Vol. 69, No. 3, 01.06.2017, p. 523-527.

Research output: Contribution to journalArticle

Fujii, K, Abe, K, Kadooka, K, Matsumoto, T & Katakura, Y 2017, 'Carnosine activates the CREB pathway in Caco-2 cells' Cytotechnology, vol. 69, no. 3, pp. 523-527. https://doi.org/10.1007/s10616-017-0089-0
Fujii, Kaoru ; Abe, Kayoko ; Kadooka, Keishi ; Matsumoto, Takashi ; Katakura, Yoshinori. / Carnosine activates the CREB pathway in Caco-2 cells. In: Cytotechnology. 2017 ; Vol. 69, No. 3. pp. 523-527.
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