TY - JOUR
T1 - Carnosine-induced antidepressant-like activity in rats
AU - Tomonaga, Shozo
AU - Yamane, Haruka
AU - Onitsuka, Eiichiro
AU - Yamada, Satoshi
AU - Sato, Mikako
AU - Takahata, Yoshihisa
AU - Morimatsu, Fumiki
AU - Furuse, Mitsuhiro
N1 - Funding Information:
The authors are grateful to the staffs and students of Laboratory of Chemistry and Technology of Animal Products in Kyushu University for their assistance in analysis of dipeptides. This work was supported by a Research Fellowship of the Japan Society for the Promotion of Science for Young Scientists (No. 189552).
PY - 2008/6
Y1 - 2008/6
N2 - Depression is a pathological state of mood and is considered as one of the major causes of disabilities. Thus, the prevention of depression and care for individuals with depression is important. In the present study, we examined whether a single oral dose of CBEX (chicken breast extract), or carnosine (one of the major components of CBEX) affects immobility time, an index of depressive-like behavior, in the forced swimming test in male Wistar rats. CBEX tended to (P = 0.09) and carnosine significantly (P < 0.05) decreased immobility time in the forced swimming test. In the hippocampus, both CBEX and carnosine significantly decreased 3-methoxy-4-hydroxyphenylglycol, a major metabolite of norepinephrine, indicating that CBEX and carnosine could reduce NE activity in the hippocampus in the forced swimming test. CBEX and carnosine did not affect total locomotive distance or rearing in the open field test, suggesting that the reductions of immobility time by both treatments in the forced swimming test were not merely due to the stimulation of general motor activity. Taken together, these results suggest that CBEX has an antidepressant-like effect, which may be due, in part, to the effect of carnosine.
AB - Depression is a pathological state of mood and is considered as one of the major causes of disabilities. Thus, the prevention of depression and care for individuals with depression is important. In the present study, we examined whether a single oral dose of CBEX (chicken breast extract), or carnosine (one of the major components of CBEX) affects immobility time, an index of depressive-like behavior, in the forced swimming test in male Wistar rats. CBEX tended to (P = 0.09) and carnosine significantly (P < 0.05) decreased immobility time in the forced swimming test. In the hippocampus, both CBEX and carnosine significantly decreased 3-methoxy-4-hydroxyphenylglycol, a major metabolite of norepinephrine, indicating that CBEX and carnosine could reduce NE activity in the hippocampus in the forced swimming test. CBEX and carnosine did not affect total locomotive distance or rearing in the open field test, suggesting that the reductions of immobility time by both treatments in the forced swimming test were not merely due to the stimulation of general motor activity. Taken together, these results suggest that CBEX has an antidepressant-like effect, which may be due, in part, to the effect of carnosine.
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U2 - 10.1016/j.pbb.2008.02.021
DO - 10.1016/j.pbb.2008.02.021
M3 - Article
C2 - 18377967
AN - SCOPUS:41949124254
SN - 0091-3057
VL - 89
SP - 627
EP - 632
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 4
ER -