Case of mucoepidermoid carcinoma of the sublingual gland accompanied with extensive dystrophic calcification and intratumoral bone formation

Yasuyuki Maruse, Shintarou Kawano, Tamotsu Kiyoshima, Yuichi Goto, Ryota Matsubara, Toru Chikui, Daigo Yoshiga, Seiji Nakamura

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3 Citations (Scopus)

Abstract

Background Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Although the histopathological findings are diverse, no case of salivary MEC accompanied with bone formation has been reported. Herein, we present the first case of MEC with intratumoral bone formation. Methods and Results A case of a 75-year-old female patient with an asymptomatic mass of the oral floor is presented. Enhanced CT revealed a tumorous mass with radiopaque materials in the oral floor. A pathological diagnosis of MEC was obtained by biopsy. Radical surgery was performed with the patient under general anesthesia. The resected specimen was finally diagnosed as MEC. Histopathologically, hyalinization, and dystrophic calcification were conspicuous within the stromal components of the tumor. Interestingly, ectopic bone formation was also found in the tumor tissues. Bony materials with osteocyte-like cells were also observed in a series of dystrophic calcification. Conclusion These findings suggest that bony materials are associated with dystrophic calcification.

Original languageEnglish
Pages (from-to)E161-E164
JournalHead and Neck
Volume37
Issue number11
DOIs
Publication statusPublished - Jan 1 2015

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Sublingual Gland
Mucoepidermoid Carcinoma
Osteogenesis
Mouth Floor
Osteocytes
Neoplasms
Salivary Glands
General Anesthesia
Biopsy

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

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title = "Case of mucoepidermoid carcinoma of the sublingual gland accompanied with extensive dystrophic calcification and intratumoral bone formation",
abstract = "Background Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Although the histopathological findings are diverse, no case of salivary MEC accompanied with bone formation has been reported. Herein, we present the first case of MEC with intratumoral bone formation. Methods and Results A case of a 75-year-old female patient with an asymptomatic mass of the oral floor is presented. Enhanced CT revealed a tumorous mass with radiopaque materials in the oral floor. A pathological diagnosis of MEC was obtained by biopsy. Radical surgery was performed with the patient under general anesthesia. The resected specimen was finally diagnosed as MEC. Histopathologically, hyalinization, and dystrophic calcification were conspicuous within the stromal components of the tumor. Interestingly, ectopic bone formation was also found in the tumor tissues. Bony materials with osteocyte-like cells were also observed in a series of dystrophic calcification. Conclusion These findings suggest that bony materials are associated with dystrophic calcification.",
author = "Yasuyuki Maruse and Shintarou Kawano and Tamotsu Kiyoshima and Yuichi Goto and Ryota Matsubara and Toru Chikui and Daigo Yoshiga and Seiji Nakamura",
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T1 - Case of mucoepidermoid carcinoma of the sublingual gland accompanied with extensive dystrophic calcification and intratumoral bone formation

AU - Maruse, Yasuyuki

AU - Kawano, Shintarou

AU - Kiyoshima, Tamotsu

AU - Goto, Yuichi

AU - Matsubara, Ryota

AU - Chikui, Toru

AU - Yoshiga, Daigo

AU - Nakamura, Seiji

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Although the histopathological findings are diverse, no case of salivary MEC accompanied with bone formation has been reported. Herein, we present the first case of MEC with intratumoral bone formation. Methods and Results A case of a 75-year-old female patient with an asymptomatic mass of the oral floor is presented. Enhanced CT revealed a tumorous mass with radiopaque materials in the oral floor. A pathological diagnosis of MEC was obtained by biopsy. Radical surgery was performed with the patient under general anesthesia. The resected specimen was finally diagnosed as MEC. Histopathologically, hyalinization, and dystrophic calcification were conspicuous within the stromal components of the tumor. Interestingly, ectopic bone formation was also found in the tumor tissues. Bony materials with osteocyte-like cells were also observed in a series of dystrophic calcification. Conclusion These findings suggest that bony materials are associated with dystrophic calcification.

AB - Background Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Although the histopathological findings are diverse, no case of salivary MEC accompanied with bone formation has been reported. Herein, we present the first case of MEC with intratumoral bone formation. Methods and Results A case of a 75-year-old female patient with an asymptomatic mass of the oral floor is presented. Enhanced CT revealed a tumorous mass with radiopaque materials in the oral floor. A pathological diagnosis of MEC was obtained by biopsy. Radical surgery was performed with the patient under general anesthesia. The resected specimen was finally diagnosed as MEC. Histopathologically, hyalinization, and dystrophic calcification were conspicuous within the stromal components of the tumor. Interestingly, ectopic bone formation was also found in the tumor tissues. Bony materials with osteocyte-like cells were also observed in a series of dystrophic calcification. Conclusion These findings suggest that bony materials are associated with dystrophic calcification.

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