Case report: Adjuvant therapy with a high dose of mitotane for adrenocortical carcinoma in a 4-year-old boy

Takako Goto, Kenichi Miyako, Ryuichi Kuromaru, Kenji Ihara, Hiroyuki Torisu, Masafumi Sanefuji, Rie Nagamatsu, Toshiro Hara

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    This report concerns control of adrenocortical carcinoma in a 4-yr-old boy by adjuvant mitotane therapy. He presented precocious puberty and was diagnosed with adrenocortical carcinoma. He underwent surgical resection, and adjuvant mitotane therapy was initiated, leading to a final dose of 5.0 g/day. Despite monitoring of the plasma mitotane level, encephalopathy developed 5 mo after initiation. Although he recovered from the encephalopathy, careful follow-up of his growth and development is necessary. On the other hand, he has been free of recurrence and metastases for 3 yr since discontinuation of mitotane. A high dose of mitotane is potentially effective as an adjuvant chemotherapy for adrenocortical carcinoma, although optimal and safe usage needs to be established for children. Copyright

    Original languageEnglish
    Pages (from-to)71-74
    Number of pages4
    JournalClinical Pediatric Endocrinology
    Volume17
    Issue number3
    DOIs
    Publication statusPublished - Jul 2008

    All Science Journal Classification (ASJC) codes

    • Pediatrics, Perinatology, and Child Health
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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