Ca2+-mediated suppression of the GABA-response through modulation of chloride channel gating in frog sensory neurones

Jan C. Behrends, Tohru Maruyama, Naofumi Tokutomi, Norio Akaike

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

A suppressant effect of intracelullar free Ca2+ on the γ-aminobutyric acid (GABA)-induced chloride inward current (ICl(GABA)) was studied in isolated frog sensory neurones under whole cell voltage clamp. Voltage-dependent Ca2+ influx elicited during the steady state of ICl(GABA)-induced a fast, slowly recovering current relaxation in the outward direction, the amplitude of which was dependent on total Ca2+ influx. This suppressant effect showed specificity for different divalent actions, suggesting action at a specific intracellular effector. Single channel recording revealed a Ca2+-dependent decrease in the duration of the open time of the GABA-gated Cl- channel without change in single channel conductance.

Original languageEnglish
Pages (from-to)311-316
Number of pages6
JournalNeuroscience Letters
Volume86
Issue number3
DOIs
Publication statusPublished - Apr 12 1988

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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