Catabolic effects of muramyl dipeptide on rabbit chondrocytes

Tetsuro Ikebe, Hideaki Iribe, Masato Hirata, Fumi Yanaga, Toshitaka Koga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Muramyl dipeptide, an essential structure for the diverse biologic activities of bacterial cell wall peptidoglycan, inhibited the synthesis of glycosaminoglycan/proteoglycan in cultured rabbit costal chondrocytes in a dose‐dependent manner. Muramyl dipeptide, as well as lipopolysaccharide and interleukin‐1α, also enhanced the release of 35S‐sulfate—prelabeled glycosaminoglycan/proteoglycan from the cell layer, which seems to reflect, at least partially, the increasing degradation of glycosaminoglycan/proteoglycan. Five synthetic analogs of muramyl dipeptide known to be adjuvant active or adjuvant inactive were tested for their potential to inhibit synthesis of glycosaminoglycan/proteoglycan and to enhance the release of glycosaminoglycan/proteoglycan in chondrocytes. The structural dependence of these synthetic analogs on chondrocytes was found to parallel that of immunoadjuvant activity. These results suggest that muramyl dipeptide is a potent mediator of catabolism in chondrocytes.

Original languageEnglish
Pages (from-to)1801-1806
Number of pages6
JournalArthritis and Rheumatism
Volume33
Issue number12
DOIs
Publication statusPublished - 1990

Fingerprint

Acetylmuramyl-Alanyl-Isoglutamine
Proteoglycans
Chondrocytes
Glycosaminoglycans
Rabbits
Immunologic Adjuvants
Peptidoglycan
Cell Wall
Lipopolysaccharides

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Ikebe, T., Iribe, H., Hirata, M., Yanaga, F., & Koga, T. (1990). Catabolic effects of muramyl dipeptide on rabbit chondrocytes. Arthritis and Rheumatism, 33(12), 1801-1806. https://doi.org/10.1002/art.1780331207

Catabolic effects of muramyl dipeptide on rabbit chondrocytes. / Ikebe, Tetsuro; Iribe, Hideaki; Hirata, Masato; Yanaga, Fumi; Koga, Toshitaka.

In: Arthritis and Rheumatism, Vol. 33, No. 12, 1990, p. 1801-1806.

Research output: Contribution to journalArticle

Ikebe, T, Iribe, H, Hirata, M, Yanaga, F & Koga, T 1990, 'Catabolic effects of muramyl dipeptide on rabbit chondrocytes', Arthritis and Rheumatism, vol. 33, no. 12, pp. 1801-1806. https://doi.org/10.1002/art.1780331207
Ikebe, Tetsuro ; Iribe, Hideaki ; Hirata, Masato ; Yanaga, Fumi ; Koga, Toshitaka. / Catabolic effects of muramyl dipeptide on rabbit chondrocytes. In: Arthritis and Rheumatism. 1990 ; Vol. 33, No. 12. pp. 1801-1806.
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