Catalytic activation of nucleophile precursors with metal acetates in alcohol media and applications to enantioselective Michael addition reactions

Fumiyasu Ono; Masayuki Hasegawa; Shuji Kanemasa; Junji Tanaka

doi:10.1016/j.tetlet.2008.05.153

Catalytic activation of nucleophile precursors with metal acetates in alcohol media and applications to enantioselective Michael addition reactions

Fumiyasu Ono, Masayuki Hasegawa, Shuji Kanemasa, Junji Tanaka

Fundamental Organic Chemistry

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

Nickel(II) acetate tetrahydrate works as catalyst to activate nucleophile precursors in Michael addition reactions. Use of alcohol media is essential for the high catalytic activation of nucleophile precursors. Catalytic enantioselective reactions using a chiral nickel(II) acetate tetrahydrate between dimedone and α,β-unsaturated amide acceptors provide a useful synthetic access to enantiomers of enol lactones through the carbon-carbon bond formation.

Original language	English
Pages (from-to)	5105-5107
Number of pages	3
Journal	Tetrahedron Letters
Volume	49
Issue number	34
DOIs	https://doi.org/10.1016/j.tetlet.2008.05.153
Publication status	Published - Aug 18 2008

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All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Ono, F., Hasegawa, M., Kanemasa, S., & Tanaka, J. (2008). Catalytic activation of nucleophile precursors with metal acetates in alcohol media and applications to enantioselective Michael addition reactions. Tetrahedron Letters, 49(34), 5105-5107. https://doi.org/10.1016/j.tetlet.2008.05.153

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10.1016/j.tetlet.2008.05.153