Catalytic asymmetric hydrogenation of 1-aza-2-cycloalkene-2-carboxylates catalyzed by a trans-chelating chiral diphosphine PhTRAP-rhodium complex

Ryoichi Kuwano, Daisuke Karube, Yoshihiko Ito

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A rhodium complex coordinated with a trans-chelating chiral diphosphine (S,S)-(R,R)-PhTRAP was an effective catalyst for asymmetric hydrogenation of N-acyl-1-aza-2-cycloalkene-2-carboxylates, which gave the corresponding protected cyclic α-amino acids with 73-97% ee.

Original languageEnglish
Pages (from-to)9045-9049
Number of pages5
JournalTetrahedron Letters
Volume40
Issue number51
DOIs
Publication statusPublished - Dec 17 1999
Externally publishedYes

Fingerprint

Cyclic Amino Acids
Cycloparaffins
Rhodium
Hydrogenation
Chelation
Catalysts

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Catalytic asymmetric hydrogenation of 1-aza-2-cycloalkene-2-carboxylates catalyzed by a trans-chelating chiral diphosphine PhTRAP-rhodium complex. / Kuwano, Ryoichi; Karube, Daisuke; Ito, Yoshihiko.

In: Tetrahedron Letters, Vol. 40, No. 51, 17.12.1999, p. 9045-9049.

Research output: Contribution to journalArticle

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