Catalytic Asymmetric Hydrogenation of Dehydroamino Acid Esters with Biscarbamate Protection and Its Application to the Synthesis of xCT Inhibitors

Yoko Yasuno, Iho Mizutani, Yuki Sueuchi, Yuuka Wakabayashi, Nozomi Yasuo, Keiko Shimamoto, Tetsuro Shinada

Research output: Contribution to journalArticle

Abstract

Catalytic asymmetric hydrogenation of dehydroamino acid esters with biscarbamate protection was examined for the first time to prepare optically active amino acids. The new method was successfully applied to the synthesis of new cystine–glutamate exchanger inhibitors.

Original languageEnglish
Pages (from-to)5145-5148
Number of pages4
JournalChemistry - A European Journal
Volume25
Issue number20
DOIs
Publication statusPublished - Apr 5 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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