Catalytic asymmetric hydrogenation of dimethyl itaconate with trans-chelating chiral diphosphine ligands TRAP-rhodium complexes

Ryoichi Kuwano, Masaya Sawamura, Yoshihiko Ito

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Asymmetric hydrogenation of dimethyl itaconate catalyzed by the trans-chelating chiral diphosphine (R,R)-(S,S)-EtTRAP-rhodium complex gave (S)-dimethyl 2-methylsuccinate with 96% ee. Dimethyl 2-isopropylidenesuccinate, a tetrasubstituted olefin substrate, was also hydrogenated with (R,R)-(S,S)-BuTRAP-rhodium complex in high enantioselectivity (78% ee), but with opposite enantioselection.

Original languageEnglish
Pages (from-to)2521-2526
Number of pages6
JournalTetrahedron: Asymmetry
Issue number10
Publication statusPublished - Oct 1995
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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