Catalytic Asymmetric Hydrogenation of Heteroarenes and Arenes

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Abstract

A trans-chelating chiral bisphosphine, PhTRAP, allows the ruthenium-catalyzed hydrogenation of various azoles to proceed with high enantioselectivity. The PhTRAP-ruthenium catalyst transformed indoles, pyrroles, imidazoles, and oxazoles into the corresponding chiral heterocycles. Naphthalenes are also reduced with hydrogen by the chiral ruthenium catalyst, exclusively giving tetralins. Some 2-alkoxytetralins were obtained with over 90% ee from the catalytic asymmetric hydrogenation of the corresponding substituted naphthalenes.

Original languageEnglish
Pages (from-to)715-719
Number of pages5
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Volume190
Issue number5-6
DOIs
Publication statusPublished - Jun 3 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

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