Abstract
An enantiocontrolled total synthesis of 19,20-dihydroakuammicine using a catalytic asymmetric MiChael addition of dimethyl malonate to cyclohexenone as the key step is described. The above catalytic asymmetric Michael addition proceeds quite efficiently in the presence of a heterobimetalic asymmetric catalyst (ALB-KO-t-Bu-MS 4A, 0.3 mol%), giving the corresponding Michael adduct in 94% yield and 99% ee. (C) 2000 Wiley-Liss, Inc.
Original language | English |
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Pages (from-to) | 400-403 |
Number of pages | 4 |
Journal | Chirality |
Volume | 12 |
Issue number | 5-6 |
DOIs | |
Publication status | Published - Jan 1 2000 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Catalysis
- Pharmacology
- Drug Discovery
- Spectroscopy
- Organic Chemistry