Cataracts after Low-Dose Radiotherapy for Lymphoproliferative Disease of the Ocular Adnexa

Sawako Hashimoto, Hiroshi Yoshikawa, Michiko Miyagi, Yoko Onishi, Ohga Saiji, Kaori Asai, Tatsuro Ishibashi

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate the interval between low-dose radiotherapy and radiation-induced cataracts, and the factors affecting this interval, in patients with lymphoproliferative disease of the ocular adnexa. Methods: A retrospective case series of 73 eyes of 59 patients who underwent radiotherapy from 1996 to 2005 with total doses ranging from 24 to 30 Gy was conducted. We investigated the relationships between the radiation-associated cataract formation intervals and age, gender, diabetes, and the use of corticosteroids. Results: The mean interval was 36 months. None of the patients with lens shield developed cataracts. Age was inversely and significantly and gender was not significantly associated with the interval from first radiotherapy to cataract occurrence. The intervals did not differ significantly according to the presence of diabetes and corticosteroid therapy. Conclusions: The mean interval from the start of radiation therapy to radiation-related cataract formation was 36 months and age was a significant factor affecting this interval.

Original languageEnglish
Pages (from-to)702-706
Number of pages5
JournalSeminars in Ophthalmology
Volume32
Issue number6
DOIs
Publication statusPublished - Nov 2 2017

Fingerprint

Cataract
Radiotherapy
Radiation
Adrenal Cortex Hormones
Lenses
Therapeutics

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Cataracts after Low-Dose Radiotherapy for Lymphoproliferative Disease of the Ocular Adnexa. / Hashimoto, Sawako; Yoshikawa, Hiroshi; Miyagi, Michiko; Onishi, Yoko; Saiji, Ohga; Asai, Kaori; Ishibashi, Tatsuro.

In: Seminars in Ophthalmology, Vol. 32, No. 6, 02.11.2017, p. 702-706.

Research output: Contribution to journalArticle

Hashimoto, Sawako ; Yoshikawa, Hiroshi ; Miyagi, Michiko ; Onishi, Yoko ; Saiji, Ohga ; Asai, Kaori ; Ishibashi, Tatsuro. / Cataracts after Low-Dose Radiotherapy for Lymphoproliferative Disease of the Ocular Adnexa. In: Seminars in Ophthalmology. 2017 ; Vol. 32, No. 6. pp. 702-706.
@article{0c2a706287364a02948010b44812b639,
title = "Cataracts after Low-Dose Radiotherapy for Lymphoproliferative Disease of the Ocular Adnexa",
abstract = "Purpose: To investigate the interval between low-dose radiotherapy and radiation-induced cataracts, and the factors affecting this interval, in patients with lymphoproliferative disease of the ocular adnexa. Methods: A retrospective case series of 73 eyes of 59 patients who underwent radiotherapy from 1996 to 2005 with total doses ranging from 24 to 30 Gy was conducted. We investigated the relationships between the radiation-associated cataract formation intervals and age, gender, diabetes, and the use of corticosteroids. Results: The mean interval was 36 months. None of the patients with lens shield developed cataracts. Age was inversely and significantly and gender was not significantly associated with the interval from first radiotherapy to cataract occurrence. The intervals did not differ significantly according to the presence of diabetes and corticosteroid therapy. Conclusions: The mean interval from the start of radiation therapy to radiation-related cataract formation was 36 months and age was a significant factor affecting this interval.",
author = "Sawako Hashimoto and Hiroshi Yoshikawa and Michiko Miyagi and Yoko Onishi and Ohga Saiji and Kaori Asai and Tatsuro Ishibashi",
year = "2017",
month = "11",
day = "2",
doi = "10.3109/08820538.2016.1170159",
language = "English",
volume = "32",
pages = "702--706",
journal = "Seminars in Ophthalmology",
issn = "0882-0538",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Cataracts after Low-Dose Radiotherapy for Lymphoproliferative Disease of the Ocular Adnexa

AU - Hashimoto, Sawako

AU - Yoshikawa, Hiroshi

AU - Miyagi, Michiko

AU - Onishi, Yoko

AU - Saiji, Ohga

AU - Asai, Kaori

AU - Ishibashi, Tatsuro

PY - 2017/11/2

Y1 - 2017/11/2

N2 - Purpose: To investigate the interval between low-dose radiotherapy and radiation-induced cataracts, and the factors affecting this interval, in patients with lymphoproliferative disease of the ocular adnexa. Methods: A retrospective case series of 73 eyes of 59 patients who underwent radiotherapy from 1996 to 2005 with total doses ranging from 24 to 30 Gy was conducted. We investigated the relationships between the radiation-associated cataract formation intervals and age, gender, diabetes, and the use of corticosteroids. Results: The mean interval was 36 months. None of the patients with lens shield developed cataracts. Age was inversely and significantly and gender was not significantly associated with the interval from first radiotherapy to cataract occurrence. The intervals did not differ significantly according to the presence of diabetes and corticosteroid therapy. Conclusions: The mean interval from the start of radiation therapy to radiation-related cataract formation was 36 months and age was a significant factor affecting this interval.

AB - Purpose: To investigate the interval between low-dose radiotherapy and radiation-induced cataracts, and the factors affecting this interval, in patients with lymphoproliferative disease of the ocular adnexa. Methods: A retrospective case series of 73 eyes of 59 patients who underwent radiotherapy from 1996 to 2005 with total doses ranging from 24 to 30 Gy was conducted. We investigated the relationships between the radiation-associated cataract formation intervals and age, gender, diabetes, and the use of corticosteroids. Results: The mean interval was 36 months. None of the patients with lens shield developed cataracts. Age was inversely and significantly and gender was not significantly associated with the interval from first radiotherapy to cataract occurrence. The intervals did not differ significantly according to the presence of diabetes and corticosteroid therapy. Conclusions: The mean interval from the start of radiation therapy to radiation-related cataract formation was 36 months and age was a significant factor affecting this interval.

UR - http://www.scopus.com/inward/record.url?scp=84978496173&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978496173&partnerID=8YFLogxK

U2 - 10.3109/08820538.2016.1170159

DO - 10.3109/08820538.2016.1170159

M3 - Article

C2 - 27420339

AN - SCOPUS:84978496173

VL - 32

SP - 702

EP - 706

JO - Seminars in Ophthalmology

JF - Seminars in Ophthalmology

SN - 0882-0538

IS - 6

ER -