TY - JOUR
T1 - Cathepsin B in the Growth of Colorectal Cancer
T2 - Increased Activity of Cathepsin B in Human Colorectal Cancer
AU - Satoh, Yasumasa
AU - Higashi, Toshihiro
AU - Nouso, Kazuhiro
AU - Shiota, Tetsuya
AU - Kinugasa, Nobuyuki
AU - Yoshida, Keigo
AU - Uematsu, Shuji
AU - Nakatsukasa, Harushige
AU - Nishimura, Yukio
AU - Tsuji, Takao
PY - 1996/12/1
Y1 - 1996/12/1
N2 - Cathepsin B, a thiol protease, is involved in cancer metastasis. To clarify the role of cathepsin B in tumor progression in human colorectal cancer, the relationship between its activity, immunohistochemical staining, and clinical tumor progression was investigated. Cathepsin B activity in adenocarcinomas was significantly elevated compared with that in the tumor-bearing tissue. Furthermore, the tumor/tumor-bearing tissue (T/Tb) ratio of the activity was significantly higher than that of colorectal adenoma. Immunohistochemical studies demonstrated intense staining in the cancerous tissue. With respect to the clinical stage of tumors, the activity tended to be higher in tumors that had invaded the serosa or subserosa than in those that invaded the proper muscle. The results suggest that cathepsin B participates in the progression of human colorectal cancer, and its increased expression is a sensitive marker of the differentiation between colorectal adenoma and adenocarcinoma.
AB - Cathepsin B, a thiol protease, is involved in cancer metastasis. To clarify the role of cathepsin B in tumor progression in human colorectal cancer, the relationship between its activity, immunohistochemical staining, and clinical tumor progression was investigated. Cathepsin B activity in adenocarcinomas was significantly elevated compared with that in the tumor-bearing tissue. Furthermore, the tumor/tumor-bearing tissue (T/Tb) ratio of the activity was significantly higher than that of colorectal adenoma. Immunohistochemical studies demonstrated intense staining in the cancerous tissue. With respect to the clinical stage of tumors, the activity tended to be higher in tumors that had invaded the serosa or subserosa than in those that invaded the proper muscle. The results suggest that cathepsin B participates in the progression of human colorectal cancer, and its increased expression is a sensitive marker of the differentiation between colorectal adenoma and adenocarcinoma.
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M3 - Article
C2 - 8985467
AN - SCOPUS:0030333716
VL - 50
SP - 305
EP - 311
JO - Acta Medica Okayama
JF - Acta Medica Okayama
SN - 0386-300X
IS - 6
ER -
