Cathepsin B in the Growth of Colorectal Cancer: Increased Activity of Cathepsin B in Human Colorectal Cancer

Yasumasa Satoh, Toshihiro Higashi, Kazuhiro Nouso, Tetsuya Shiota, Nobuyuki Kinugasa, Keigo Yoshida, Shuji Uematsu, Harushige Nakatsukasa, Yukio Nishimura, Takao Tsuji

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Abstract

Cathepsin B, a thiol protease, is involved in cancer metastasis. To clarify the role of cathepsin B in tumor progression in human colorectal cancer, the relationship between its activity, immunohistochemical staining, and clinical tumor progression was investigated. Cathepsin B activity in adenocarcinomas was significantly elevated compared with that in the tumor-bearing tissue. Furthermore, the tumor/tumor-bearing tissue (T/Tb) ratio of the activity was significantly higher than that of colorectal adenoma. Immunohistochemical studies demonstrated intense staining in the cancerous tissue. With respect to the clinical stage of tumors, the activity tended to be higher in tumors that had invaded the serosa or subserosa than in those that invaded the proper muscle. The results suggest that cathepsin B participates in the progression of human colorectal cancer, and its increased expression is a sensitive marker of the differentiation between colorectal adenoma and adenocarcinoma.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalActa medica Okayama
Volume50
Issue number6
Publication statusPublished - Dec 1 1996

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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    Satoh, Y., Higashi, T., Nouso, K., Shiota, T., Kinugasa, N., Yoshida, K., Uematsu, S., Nakatsukasa, H., Nishimura, Y., & Tsuji, T. (1996). Cathepsin B in the Growth of Colorectal Cancer: Increased Activity of Cathepsin B in Human Colorectal Cancer. Acta medica Okayama, 50(6), 305-311.