A novel 1,3-alternate calixbiscrown was synthesized by the reaction of calixarene and tetraethyleneglycol ditosylate in the presence of K2 CO3. It formed a 1:2 complex as well as a 1:1 complex with alkali metal and ammonium cations and the cation tunneling phenomenon across the calixarene cavity was detectable with 1H NMR spectroscopy even at room temperature.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry