Cationic comb-type copolymers for boosting DNA-fueled nanomachines

Sung Won Choi; Naoki Makita; Satoru Inoue; Charles Lesoil; Asako Yamayoshi; Arihiro Kano; Toshihiro Akaike; Atsushi Maruyama

doi:10.1021/nl0626232

Cationic comb-type copolymers for boosting DNA-fueled nanomachines

Sung Won Choi, Naoki Makita, Satoru Inoue, Charles Lesoil, Asako Yamayoshi, Arihiro Kano, Toshihiro Akaike, Atsushi Maruyama

Fundamental Organic Chemistry

Research output: Contribution to journal › Article

30 Citations (Scopus)

Abstract

For the better applications and developments of DNA nanomachines, their responding kinetics, output, and sequence-selectivity need to be improved. Furthermore, the DNA nanomachines currently have several limitations in operating conditions. Here we show that a simple addition of a cationic comb-type copolymer, poly(L-lysine)-graft-dextran, produces the robust and quick responses of DNA nanomachines under moderate conditions including physiologically relevant conditions even at very low strand concentrations (nanomoles per liter range) through hybrid stabilization and DNA strand exchange acceleration.

Original language	English
Pages (from-to)	172-178
Number of pages	7
Journal	Nano Letters
Volume	7
Issue number	1
DOIs	https://doi.org/10.1021/nl0626232
Publication status	Published - Jan 2007

Fingerprint

All Science Journal Classification (ASJC) codes

Materials Science(all)
Electronic, Optical and Magnetic Materials
Chemistry (miscellaneous)

Cite this

Choi, S. W., Makita, N., Inoue, S., Lesoil, C., Yamayoshi, A., Kano, A., ... Maruyama, A. (2007). Cationic comb-type copolymers for boosting DNA-fueled nanomachines. Nano Letters, 7(1), 172-178. https://doi.org/10.1021/nl0626232

@article{365223f76b224f03aa43c7e93f8abe42,

title = "Cationic comb-type copolymers for boosting DNA-fueled nanomachines",

abstract = "For the better applications and developments of DNA nanomachines, their responding kinetics, output, and sequence-selectivity need to be improved. Furthermore, the DNA nanomachines currently have several limitations in operating conditions. Here we show that a simple addition of a cationic comb-type copolymer, poly(L-lysine)-graft-dextran, produces the robust and quick responses of DNA nanomachines under moderate conditions including physiologically relevant conditions even at very low strand concentrations (nanomoles per liter range) through hybrid stabilization and DNA strand exchange acceleration.",

author = "Choi, {Sung Won} and Naoki Makita and Satoru Inoue and Charles Lesoil and Asako Yamayoshi and Arihiro Kano and Toshihiro Akaike and Atsushi Maruyama",

year = "2007",

month = "1",

doi = "10.1021/nl0626232",

language = "English",

volume = "7",

pages = "172--178",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Cationic comb-type copolymers for boosting DNA-fueled nanomachines

AU - Choi, Sung Won

AU - Makita, Naoki

AU - Inoue, Satoru

AU - Lesoil, Charles

AU - Yamayoshi, Asako

AU - Kano, Arihiro

AU - Akaike, Toshihiro

AU - Maruyama, Atsushi

PY - 2007/1

Y1 - 2007/1

N2 - For the better applications and developments of DNA nanomachines, their responding kinetics, output, and sequence-selectivity need to be improved. Furthermore, the DNA nanomachines currently have several limitations in operating conditions. Here we show that a simple addition of a cationic comb-type copolymer, poly(L-lysine)-graft-dextran, produces the robust and quick responses of DNA nanomachines under moderate conditions including physiologically relevant conditions even at very low strand concentrations (nanomoles per liter range) through hybrid stabilization and DNA strand exchange acceleration.

AB - For the better applications and developments of DNA nanomachines, their responding kinetics, output, and sequence-selectivity need to be improved. Furthermore, the DNA nanomachines currently have several limitations in operating conditions. Here we show that a simple addition of a cationic comb-type copolymer, poly(L-lysine)-graft-dextran, produces the robust and quick responses of DNA nanomachines under moderate conditions including physiologically relevant conditions even at very low strand concentrations (nanomoles per liter range) through hybrid stabilization and DNA strand exchange acceleration.

UR - http://www.scopus.com/inward/record.url?scp=33846876315&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846876315&partnerID=8YFLogxK

U2 - 10.1021/nl0626232

DO - 10.1021/nl0626232

M3 - Article

C2 - 17212459

AN - SCOPUS:33846876315

VL - 7

SP - 172

EP - 178

JO - Nano Letters

JF - Nano Letters

SN - 1530-6984

IS - 1

ER -

Access to Document

10.1021/nl0626232