TY - JOUR
T1 - CD20-positive plasma cell myeloma with lymphoplasmacytoid appearance mimicking low-grade B-cell lymphoma
AU - Haji, Shojiro
AU - Abe, Yasunobu
AU - Tsuda, Mariko
AU - Toyoda, Kosuke
AU - Choi, Ilseung
AU - Suehiro, Youko
AU - Shiratsuchi, Motoaki
AU - Kiyasu, Junichi
AU - Uike, Naokuni
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2015/3/1
Y1 - 2015/3/1
N2 - CD 20 positive myeloma with small lymphoplasmacytoid morphology is difficult to differentiate from mature B-cell lymphoma. A 71-year-old male was referred to our hospital because of osteolytic vertebral fractures and anemia. Urine was positive for Bence Jones protein, κ type. Bone marrow consisted of approximately 30% small lymphoplasmacytoid cells with scant cytoplasm, and these cells were positive for CD20, CD23 and CD138. FISH analysis revealed t(11;14)(CCND1/IGH). Myeloma with t(11;14) is closely associated with small lymphoplasmacytoid appearance and CD20 and CD23 expressions. The patient was diagnosed as having myeloma based on clinical and cytogenetic findings, and achieved VGPR (very good partial response) after treatment with lenalidomide.
AB - CD 20 positive myeloma with small lymphoplasmacytoid morphology is difficult to differentiate from mature B-cell lymphoma. A 71-year-old male was referred to our hospital because of osteolytic vertebral fractures and anemia. Urine was positive for Bence Jones protein, κ type. Bone marrow consisted of approximately 30% small lymphoplasmacytoid cells with scant cytoplasm, and these cells were positive for CD20, CD23 and CD138. FISH analysis revealed t(11;14)(CCND1/IGH). Myeloma with t(11;14) is closely associated with small lymphoplasmacytoid appearance and CD20 and CD23 expressions. The patient was diagnosed as having myeloma based on clinical and cytogenetic findings, and achieved VGPR (very good partial response) after treatment with lenalidomide.
UR - http://www.scopus.com/inward/record.url?scp=84946745974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946745974&partnerID=8YFLogxK
U2 - 10.11406/rinketsu.56.335
DO - 10.11406/rinketsu.56.335
M3 - Article
C2 - 25876789
AN - SCOPUS:84946745974
VL - 56
SP - 335
EP - 338
JO - [Rinsho ketsueki] The Japanese journal of clinical hematology
JF - [Rinsho ketsueki] The Japanese journal of clinical hematology
SN - 0485-1439
IS - 3
ER -