CD24 modulates chemosensitivity of MCF-7 breast cancer cells

Hideya Onishi, Kumi Suyama, Akio Yamasaki, Yasuhiro Oyama, Akiko Fujimura, Makoto Kawamoto, Akira Imaizumi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The role of cluster of differentiation (CD) 24 in breast cancer remains unclear; previously, we showed that CD24 suppresses malignant phenotypes by inactivating Hedgehog signaling through signal transducer and activator of transcription (STAT) 1 inhibition. In this study, we examined how CD24 affects chemosensitivity in breast cancer cells. The CD44+CD24+ breast cancer cell line MCF-7 was transfected with CD24 with/without STAT1 siRNA, and chemosensitivity to 5-fluorouracil (5-FU) and cis-diamminedichloroplatinum (CDDP) was measured. CD24 inhibition reduced chemosensitivity to 5-FU, while STAT1 inhibition did not affect chemosensitivity to 5-FU in CD24 siRNA-transfected cells. Conversely, CD24 inhibition did not affect chemosensitivity to CDDP, while STAT1 inhibition reduced chemosensitivity to CDDP in CD24 siRNA-transfected cells. STAT1 inhibition, but not CD24 inhibition, reduced expression of the ATP-binding cassette (ABC) transporter genes, ABCB1 and ABCG2. In conclusion, CD24 inhibition may modulate chemosensitivity according to drug type, but ABC transporter expression appears not to contribute to this mechanism. This study contributes to determining the role of CD24 in breast cancer.

Original languageEnglish
Pages (from-to)561-566
Number of pages6
JournalAnticancer research
Volume37
Issue number2
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Onishi, H., Suyama, K., Yamasaki, A., Oyama, Y., Fujimura, A., Kawamoto, M., & Imaizumi, A. (2017). CD24 modulates chemosensitivity of MCF-7 breast cancer cells. Anticancer research, 37(2), 561-566. https://doi.org/10.21873/anticanres.11349