CD34 expression in endothelial cells of small hepatocellular carcinoma: Its correlation with tumour progression and angiographic findings

TAKASHI MAEDA, EISUKE ADACHI, KIYOSHI KAJIYAMA, KENJI TAKENAKA, HIROSHI HONDA, KEIZO SUGIMACHI, MASAZUMI TSUNEYOSHI

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Abstract

The angiogenic process plays an important role in tumour growth and metastasis during hepatocarcinogenesis, but it is still uncertain when the process begins during tumour formation. Forty‐two small hepatocellular carcinomas (HCC) that measured either less than or equal to 2 cm in diameter were studied by comparing the histologic findings with the angiographic findings, and with immunohistochemical expression of endothelial marker QB‐end/10 (QB), a new monoclonal antibody raised against CD34, in the sinusoidal wall. Twenty (91%) of 22 moderately or poorly differentiated HCC revealed a positive reaction for QB, while only eight (40%) of 20 well differentiated HCC demonstrated a positive reaction (P < 0.01). In the tumours showing a ‘nodule in nodule’ appearance, the less differentiated areas were more reactive for QB. Twenty‐three (82%) of 28 QB positive tumours were hypervascular, while only three of 14 (21%) QB negative tumours were hypervascular (P < 0.01) by angiography. All six of the poorly differentiated and 13 (81%) of the 16 moderately differentiated tumours were hypervascular, while only seven (35%) of 20 well differentiated HCC were hypervascular (P < 0.01). These results indicate that as the tumour becomes less differentiated, the QB positive areas become wider and angiography demonstrates hypervascularity. We therefore speculate that the HCC sinusoids acquire the characteristics of capillary and precapillary blood vessels during de‐differentiation from well to moderate, and thus the tumour begins to reveal hypervascularity on angiography. The above process may be correlated with the stepwise progression of HCC.

Original languageEnglish
Pages (from-to)650-654
Number of pages5
JournalJournal of Gastroenterology and Hepatology
Volume10
Issue number6
DOIs
Publication statusPublished - Dec 1995

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Hepatocellular Carcinoma
Endothelial Cells
Neoplasms
Angiography
Blood Vessels
Monoclonal Antibodies
Neoplasm Metastasis
Growth

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

MAEDA, TAKASHI., ADACHI, EISUKE., KAJIYAMA, KIYOSHI., TAKENAKA, KENJI., HONDA, HIROSHI., SUGIMACHI, KEIZO., & TSUNEYOSHI, MASAZUMI. (1995). CD34 expression in endothelial cells of small hepatocellular carcinoma: Its correlation with tumour progression and angiographic findings. Journal of Gastroenterology and Hepatology, 10(6), 650-654. https://doi.org/10.1111/j.1440-1746.1995.tb01365.x

CD34 expression in endothelial cells of small hepatocellular carcinoma : Its correlation with tumour progression and angiographic findings. / MAEDA, TAKASHI; ADACHI, EISUKE; KAJIYAMA, KIYOSHI; TAKENAKA, KENJI; HONDA, HIROSHI; SUGIMACHI, KEIZO; TSUNEYOSHI, MASAZUMI.

In: Journal of Gastroenterology and Hepatology, Vol. 10, No. 6, 12.1995, p. 650-654.

Research output: Contribution to journalArticle

MAEDA, TAKASHI, ADACHI, EISUKE, KAJIYAMA, KIYOSHI, TAKENAKA, KENJI, HONDA, HIROSHI, SUGIMACHI, KEIZO & TSUNEYOSHI, MASAZUMI 1995, 'CD34 expression in endothelial cells of small hepatocellular carcinoma: Its correlation with tumour progression and angiographic findings', Journal of Gastroenterology and Hepatology, vol. 10, no. 6, pp. 650-654. https://doi.org/10.1111/j.1440-1746.1995.tb01365.x
MAEDA, TAKASHI ; ADACHI, EISUKE ; KAJIYAMA, KIYOSHI ; TAKENAKA, KENJI ; HONDA, HIROSHI ; SUGIMACHI, KEIZO ; TSUNEYOSHI, MASAZUMI. / CD34 expression in endothelial cells of small hepatocellular carcinoma : Its correlation with tumour progression and angiographic findings. In: Journal of Gastroenterology and Hepatology. 1995 ; Vol. 10, No. 6. pp. 650-654.
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