CD4 expression is important but not essential for infection with exogenous mouse mammary tumor virus

Yoshohiro Ando, Worawidh Wajjwalku, Kenji Kishihara, Toshiyuki Arai, Naoya Niimi, Kenji Hiromatsu, Tsuneo Morishima, Yasunobu Yoshikai

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We studied local events in the popliteal lymph nodes of CD4-deficient mice following foot pad injection with an MMTV strain which carries the gene for a Vβ14-specific superantigen. Injection of the Vβ14-specific MMTV induced vigorous expansion of Vβ14+ CD4+ T cells and B cells in their lymph nodes of CD4+/- heterozygous control mice. On the other hand, CD4-/- mice injected with the MMTV showed a proliferation of Vβ14+ T cells among the population of TCRαβ+ CD4-CD8- T cells, although to a lesser extent. This phenomenon was not accompanied by vigorous B cell expansion. A PCR assay revelated that the MMTV definitely infected the lymph nodes cells of the CD4-/- mouse. However, the infectivity of the MMTV in CD4-/- mice was approximately 20 times lower than that in CD4+/- mice. These findings indicate that, in MMTV infection of CD4-deficient mice, the superantigen-reactive T cells among the population of TCRαβ+ CD4(z)CD8(x) T cells substitute for the superantigen-reactive CD4+ T cells of normal mice, and that the absence of CD4 molecules decreased the infectivity of MMTV because of insufficient expansion of the superantigen-reactive T cells.

    Original languageEnglish
    Pages (from-to)376-384
    Number of pages9
    JournalImmunobiology
    Volume195
    Issue number3
    DOIs
    Publication statusPublished - Aug 1996

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology
    • Hematology

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