CD44 expression in normal human skin and skin tumors

N. Yasaka, Masutaka Furue, K. Tamaki

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

CD44 is thought to be a principal cell surface receptor for hyaluronic acid. Although the distribution of hyalulonic acid has been studied, little is known about the distribution of the CD44 molecule in the human skin and skin tumors. This study was undertaken to investigate the distribution of the CD44 molecule in normal human skin as well as in benign and malignant skin tumors. In normal skin, CD44 was expressed on 1) keratinocyte cell surfaces throughout the epidermis except for the granular and horny layers, 2) hair follicular cells, 3) eccrine sweat gland cells, and 4) cell surfaces of dendritic cells in the dermis. In skin tumors, although CD44 was expressed on the tumor cell surface of seborreic keratosis, Bowen's disease, and squamous cell carcinoma as in normal skin, we could not detect any CD44 expression on the cell surface of the tumor cells of basal cell carcinoma. However, CD44 positive dendritic cells were observed in the tumor islands of basal cell carcinoma. Phenotypic analysis suggested that these CD44 positive cells were melanocytes.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalJournal of Dermatology
Volume22
Issue number2
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

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Skin
Neoplasms
Basal Cell Carcinoma
Dendritic Cells
Eccrine Glands
Bowen's Disease
Keratosis
Sweat Glands
Melanocytes
Cell Surface Receptors
Hyaluronic Acid
Dermis
Keratinocytes
Epidermis
Hair
Squamous Cell Carcinoma
Acids

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

CD44 expression in normal human skin and skin tumors. / Yasaka, N.; Furue, Masutaka; Tamaki, K.

In: Journal of Dermatology, Vol. 22, No. 2, 01.01.1995, p. 88-94.

Research output: Contribution to journalArticle

Yasaka, N. ; Furue, Masutaka ; Tamaki, K. / CD44 expression in normal human skin and skin tumors. In: Journal of Dermatology. 1995 ; Vol. 22, No. 2. pp. 88-94.
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