CD4/Leu7 and CD8/Leu7 large granular lymphocytosis: comparative studies between NK cells and T cells.

S. Nishinarita, Y. Iizuka, H. Kang, N. Kubo, M. Sakurada, K. Kamei, Yusuke Yanagi, M. Akahoshi, K. Oshimi, S. Sawada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Lymphocytes, co-expressing CD4/Leu7 and CD8/Leu7 markers respectively, taken from two patients having large granular lymphocytosis taking an indolent clinical course have been comparatively studied for function as NK cells and T cells. Both large granular lymphocytes (LGLs) were acid phosphatase positive and showed a beta-glucuronidase reaction in their cytoplasmic granules. Studies on case 1 indicated that the CD4/Leu7 lymphocytosis with LGL morphology takes a benign clinical course with mild neutropenia as well as those of CD8/Leu7 LG lymphocytosis. Both CD4/Leu7 and CD8/Leu7 LGLs behave similarly in their lack of NK activity, and manifest decreased IL-2 production in vitro and show a low IL-2 receptor expression unrelated to their T cell phenotype, but behave differently in influencing the immunoglobulin production in vitro and the ADCC activity, depending on their T cell phenotype and on the expression of Fc receptor, respectively. Furthermore, the altered Fc receptors which were undetectable by the Leul 1 antibody but were still effective for ADCC activity might be present in case 2 LGLs.

Original languageEnglish
Pages (from-to)1045-1057
Number of pages13
JournalActa Haematologica Japonica
Volume52
Issue number6
Publication statusPublished - Sep 1 1989

Fingerprint

Large Granular Lymphocytic Leukemia
Natural Killer Cells
Lymphocytes
T-Lymphocytes
Antibody-Dependent Cell Cytotoxicity
Fc Receptors
Cytoplasmic Granules
Phenotype
Lymphocytosis
Interleukin-2 Receptors
Glucuronidase
Acid Phosphatase
Neutropenia
Interleukin-2
Immunoglobulins
Antibodies

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Nishinarita, S., Iizuka, Y., Kang, H., Kubo, N., Sakurada, M., Kamei, K., ... Sawada, S. (1989). CD4/Leu7 and CD8/Leu7 large granular lymphocytosis: comparative studies between NK cells and T cells. Acta Haematologica Japonica, 52(6), 1045-1057.

CD4/Leu7 and CD8/Leu7 large granular lymphocytosis : comparative studies between NK cells and T cells. / Nishinarita, S.; Iizuka, Y.; Kang, H.; Kubo, N.; Sakurada, M.; Kamei, K.; Yanagi, Yusuke; Akahoshi, M.; Oshimi, K.; Sawada, S.

In: Acta Haematologica Japonica, Vol. 52, No. 6, 01.09.1989, p. 1045-1057.

Research output: Contribution to journalArticle

Nishinarita, S, Iizuka, Y, Kang, H, Kubo, N, Sakurada, M, Kamei, K, Yanagi, Y, Akahoshi, M, Oshimi, K & Sawada, S 1989, 'CD4/Leu7 and CD8/Leu7 large granular lymphocytosis: comparative studies between NK cells and T cells.', Acta Haematologica Japonica, vol. 52, no. 6, pp. 1045-1057.
Nishinarita S, Iizuka Y, Kang H, Kubo N, Sakurada M, Kamei K et al. CD4/Leu7 and CD8/Leu7 large granular lymphocytosis: comparative studies between NK cells and T cells. Acta Haematologica Japonica. 1989 Sep 1;52(6):1045-1057.
Nishinarita, S. ; Iizuka, Y. ; Kang, H. ; Kubo, N. ; Sakurada, M. ; Kamei, K. ; Yanagi, Yusuke ; Akahoshi, M. ; Oshimi, K. ; Sawada, S. / CD4/Leu7 and CD8/Leu7 large granular lymphocytosis : comparative studies between NK cells and T cells. In: Acta Haematologica Japonica. 1989 ; Vol. 52, No. 6. pp. 1045-1057.
@article{f09d0dca77fe4bbe8262111cbd4744d6,
title = "CD4/Leu7 and CD8/Leu7 large granular lymphocytosis: comparative studies between NK cells and T cells.",
abstract = "Lymphocytes, co-expressing CD4/Leu7 and CD8/Leu7 markers respectively, taken from two patients having large granular lymphocytosis taking an indolent clinical course have been comparatively studied for function as NK cells and T cells. Both large granular lymphocytes (LGLs) were acid phosphatase positive and showed a beta-glucuronidase reaction in their cytoplasmic granules. Studies on case 1 indicated that the CD4/Leu7 lymphocytosis with LGL morphology takes a benign clinical course with mild neutropenia as well as those of CD8/Leu7 LG lymphocytosis. Both CD4/Leu7 and CD8/Leu7 LGLs behave similarly in their lack of NK activity, and manifest decreased IL-2 production in vitro and show a low IL-2 receptor expression unrelated to their T cell phenotype, but behave differently in influencing the immunoglobulin production in vitro and the ADCC activity, depending on their T cell phenotype and on the expression of Fc receptor, respectively. Furthermore, the altered Fc receptors which were undetectable by the Leul 1 antibody but were still effective for ADCC activity might be present in case 2 LGLs.",
author = "S. Nishinarita and Y. Iizuka and H. Kang and N. Kubo and M. Sakurada and K. Kamei and Yusuke Yanagi and M. Akahoshi and K. Oshimi and S. Sawada",
year = "1989",
month = "9",
day = "1",
language = "English",
volume = "52",
pages = "1045--1057",
journal = "International Journal of Hematology",
issn = "0925-5710",
publisher = "Springer Japan",
number = "6",

}

TY - JOUR

T1 - CD4/Leu7 and CD8/Leu7 large granular lymphocytosis

T2 - comparative studies between NK cells and T cells.

AU - Nishinarita, S.

AU - Iizuka, Y.

AU - Kang, H.

AU - Kubo, N.

AU - Sakurada, M.

AU - Kamei, K.

AU - Yanagi, Yusuke

AU - Akahoshi, M.

AU - Oshimi, K.

AU - Sawada, S.

PY - 1989/9/1

Y1 - 1989/9/1

N2 - Lymphocytes, co-expressing CD4/Leu7 and CD8/Leu7 markers respectively, taken from two patients having large granular lymphocytosis taking an indolent clinical course have been comparatively studied for function as NK cells and T cells. Both large granular lymphocytes (LGLs) were acid phosphatase positive and showed a beta-glucuronidase reaction in their cytoplasmic granules. Studies on case 1 indicated that the CD4/Leu7 lymphocytosis with LGL morphology takes a benign clinical course with mild neutropenia as well as those of CD8/Leu7 LG lymphocytosis. Both CD4/Leu7 and CD8/Leu7 LGLs behave similarly in their lack of NK activity, and manifest decreased IL-2 production in vitro and show a low IL-2 receptor expression unrelated to their T cell phenotype, but behave differently in influencing the immunoglobulin production in vitro and the ADCC activity, depending on their T cell phenotype and on the expression of Fc receptor, respectively. Furthermore, the altered Fc receptors which were undetectable by the Leul 1 antibody but were still effective for ADCC activity might be present in case 2 LGLs.

AB - Lymphocytes, co-expressing CD4/Leu7 and CD8/Leu7 markers respectively, taken from two patients having large granular lymphocytosis taking an indolent clinical course have been comparatively studied for function as NK cells and T cells. Both large granular lymphocytes (LGLs) were acid phosphatase positive and showed a beta-glucuronidase reaction in their cytoplasmic granules. Studies on case 1 indicated that the CD4/Leu7 lymphocytosis with LGL morphology takes a benign clinical course with mild neutropenia as well as those of CD8/Leu7 LG lymphocytosis. Both CD4/Leu7 and CD8/Leu7 LGLs behave similarly in their lack of NK activity, and manifest decreased IL-2 production in vitro and show a low IL-2 receptor expression unrelated to their T cell phenotype, but behave differently in influencing the immunoglobulin production in vitro and the ADCC activity, depending on their T cell phenotype and on the expression of Fc receptor, respectively. Furthermore, the altered Fc receptors which were undetectable by the Leul 1 antibody but were still effective for ADCC activity might be present in case 2 LGLs.

UR - http://www.scopus.com/inward/record.url?scp=0024723219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024723219&partnerID=8YFLogxK

M3 - Article

C2 - 2511716

AN - SCOPUS:0024723219

VL - 52

SP - 1045

EP - 1057

JO - International Journal of Hematology

JF - International Journal of Hematology

SN - 0925-5710

IS - 6

ER -