Abstract
We describe a 17-year-old woman with chronic active Epstein-Barr virus infection (CAEBV), who developed EBV+CD4-CD8- T-cell polymyositis. At 14 years of age, CAEBV was diagnosed with fever, cytopenia, liver dysfunction, and hepatosplenomegaly. Despite the transient remission of interferon-α therapy, migratory lesions emerged in back and extremities. MRI indicated polymyositis. Biopsy specimens revealed intramuscular infiltration of CD3+, CD4-, CD8-, CD56-, and EBV-encoded RNA 1+ cells. Circulating CD4-CD8-Vδ2/Vγ9 cells increased. γδT-cells contained 20-200 times higher EBV-DNA (2 x 104 copies/μgDNA) than αβT-cells or NK-cells. The ominous polymyositis might denote the musculotropic invasion of EBV+γδT-cell lymphoproliferative disease as a consequence of CAEBV.
| Original language | English |
|---|---|
| Pages (from-to) | 211-215 |
| Number of pages | 5 |
| Journal | American Journal of Hematology |
| Volume | 71 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Nov 1 2002 |
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All Science Journal Classification (ASJC) codes
- Hematology
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CD4-CD8- T-cell polymyositis in a patient with chronic active Epstein-Barr virus infection. / Tsutsumi, Sachiko; Ohga, Shouichi; Nomura, Akihiko; Takada, Hidetoshi; Sakai, Shuji; Ohshima, Koichi; Sumimoto, Kotoko; Hara, Toshiro.
In: American Journal of Hematology, Vol. 71, No. 3, 01.11.2002, p. 211-215.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CD4-CD8- T-cell polymyositis in a patient with chronic active Epstein-Barr virus infection
AU - Tsutsumi, Sachiko
AU - Ohga, Shouichi
AU - Nomura, Akihiko
AU - Takada, Hidetoshi
AU - Sakai, Shuji
AU - Ohshima, Koichi
AU - Sumimoto, Kotoko
AU - Hara, Toshiro
PY - 2002/11/1
Y1 - 2002/11/1
N2 - We describe a 17-year-old woman with chronic active Epstein-Barr virus infection (CAEBV), who developed EBV+CD4-CD8- T-cell polymyositis. At 14 years of age, CAEBV was diagnosed with fever, cytopenia, liver dysfunction, and hepatosplenomegaly. Despite the transient remission of interferon-α therapy, migratory lesions emerged in back and extremities. MRI indicated polymyositis. Biopsy specimens revealed intramuscular infiltration of CD3+, CD4-, CD8-, CD56-, and EBV-encoded RNA 1+ cells. Circulating CD4-CD8-Vδ2/Vγ9 cells increased. γδT-cells contained 20-200 times higher EBV-DNA (2 x 104 copies/μgDNA) than αβT-cells or NK-cells. The ominous polymyositis might denote the musculotropic invasion of EBV+γδT-cell lymphoproliferative disease as a consequence of CAEBV.
AB - We describe a 17-year-old woman with chronic active Epstein-Barr virus infection (CAEBV), who developed EBV+CD4-CD8- T-cell polymyositis. At 14 years of age, CAEBV was diagnosed with fever, cytopenia, liver dysfunction, and hepatosplenomegaly. Despite the transient remission of interferon-α therapy, migratory lesions emerged in back and extremities. MRI indicated polymyositis. Biopsy specimens revealed intramuscular infiltration of CD3+, CD4-, CD8-, CD56-, and EBV-encoded RNA 1+ cells. Circulating CD4-CD8-Vδ2/Vγ9 cells increased. γδT-cells contained 20-200 times higher EBV-DNA (2 x 104 copies/μgDNA) than αβT-cells or NK-cells. The ominous polymyositis might denote the musculotropic invasion of EBV+γδT-cell lymphoproliferative disease as a consequence of CAEBV.
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UR - http://www.scopus.com/inward/citedby.url?scp=0036830107&partnerID=8YFLogxK
U2 - 10.1002/ajh.10207
DO - 10.1002/ajh.10207
M3 - Article
C2 - 12410578
AN - SCOPUS:0036830107
VL - 71
SP - 211
EP - 215
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 3
ER -