CD4-CD8- T-cell polymyositis in a patient with chronic active Epstein-Barr virus infection

Sachiko Tsutsumi, Shouichi Ohga, Akihiko Nomura, Hidetoshi Takada, Shuji Sakai, Koichi Ohshima, Kotoko Sumimoto, Toshiro Hara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We describe a 17-year-old woman with chronic active Epstein-Barr virus infection (CAEBV), who developed EBV+CD4-CD8- T-cell polymyositis. At 14 years of age, CAEBV was diagnosed with fever, cytopenia, liver dysfunction, and hepatosplenomegaly. Despite the transient remission of interferon-α therapy, migratory lesions emerged in back and extremities. MRI indicated polymyositis. Biopsy specimens revealed intramuscular infiltration of CD3+, CD4-, CD8-, CD56-, and EBV-encoded RNA 1+ cells. Circulating CD4-CD8-Vδ2/Vγ9 cells increased. γδT-cells contained 20-200 times higher EBV-DNA (2 x 104 copies/μgDNA) than αβT-cells or NK-cells. The ominous polymyositis might denote the musculotropic invasion of EBV+γδT-cell lymphoproliferative disease as a consequence of CAEBV.

Original languageEnglish
Pages (from-to)211-215
Number of pages5
JournalAmerican Journal of Hematology
Volume71
Issue number3
DOIs
Publication statusPublished - Nov 1 2002

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Polymyositis
Epstein-Barr Virus Infections
Human Herpesvirus 4
T-Lymphocytes
Natural Killer Cells
Interferons
Liver Diseases
Fever
Extremities
RNA
Biopsy
DNA
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

CD4-CD8- T-cell polymyositis in a patient with chronic active Epstein-Barr virus infection. / Tsutsumi, Sachiko; Ohga, Shouichi; Nomura, Akihiko; Takada, Hidetoshi; Sakai, Shuji; Ohshima, Koichi; Sumimoto, Kotoko; Hara, Toshiro.

In: American Journal of Hematology, Vol. 71, No. 3, 01.11.2002, p. 211-215.

Research output: Contribution to journalArticle

Tsutsumi, S, Ohga, S, Nomura, A, Takada, H, Sakai, S, Ohshima, K, Sumimoto, K & Hara, T 2002, 'CD4-CD8- T-cell polymyositis in a patient with chronic active Epstein-Barr virus infection', American Journal of Hematology, vol. 71, no. 3, pp. 211-215. https://doi.org/10.1002/ajh.10207
Tsutsumi, Sachiko ; Ohga, Shouichi ; Nomura, Akihiko ; Takada, Hidetoshi ; Sakai, Shuji ; Ohshima, Koichi ; Sumimoto, Kotoko ; Hara, Toshiro. / CD4-CD8- T-cell polymyositis in a patient with chronic active Epstein-Barr virus infection. In: American Journal of Hematology. 2002 ; Vol. 71, No. 3. pp. 211-215.
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