Abstract
Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25 +Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.
| Original language | English |
|---|---|
| Pages (from-to) | 87-90 |
| Number of pages | 4 |
| Journal | Metabolic Brain Disease |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 1 2011 |
| Externally published | Yes |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry
- Clinical Neurology
- Cellular and Molecular Neuroscience
Cite this
CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke. / Ren, Xuefang; akiyoshi, kozaburo; Vandenbark, Arthur A.; Hurn, Patricia D.; Offner, Halina.
In: Metabolic Brain Disease, Vol. 26, No. 1, 01.03.2011, p. 87-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke
AU - Ren, Xuefang
AU - akiyoshi, kozaburo
AU - Vandenbark, Arthur A.
AU - Hurn, Patricia D.
AU - Offner, Halina
PY - 2011/3/1
Y1 - 2011/3/1
N2 - Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25 +Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.
AB - Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25 +Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.
UR - http://www.scopus.com/inward/record.url?scp=79955083477&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955083477&partnerID=8YFLogxK
U2 - 10.1007/s11011-010-9226-6
DO - 10.1007/s11011-010-9226-6
M3 - Article
VL - 26
SP - 87
EP - 90
JO - Metabolic Brain Disease
JF - Metabolic Brain Disease
SN - 0885-7490
IS - 1
ER -