CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke

Xuefang Ren, Kozaburo Akiyoshi, Arthur A. Vandenbark, Patricia D. Hurn, Halina Offner

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79 Citations (Scopus)

Abstract

Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25 +Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalMetabolic Brain Disease
Volume26
Issue number1
DOIs
Publication statusPublished - Mar 1 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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    Ren, X., Akiyoshi, K., Vandenbark, A. A., Hurn, P. D., & Offner, H. (2011). CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke. Metabolic Brain Disease, 26(1), 87-90. https://doi.org/10.1007/s11011-010-9226-6