TY - JOUR
T1 - CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke
AU - Ren, Xuefang
AU - Akiyoshi, Kozaburo
AU - Vandenbark, Arthur A.
AU - Hurn, Patricia D.
AU - Offner, Halina
N1 - Funding Information:
Acknowledgments The authors wish to thank Dr. Sushmita Sinha, Ms. Sandhya Subramanian and Dr. Suzan Dziennis for helpful discussions and Ms. Eva Niehaus and Heather Hoem for assistance in preparing the manuscript. This work was supported by NIH grant NR03521 and the Biomedical Laboratory R&D Service, Department of Veterans Affairs.
PY - 2011/3
Y1 - 2011/3
N2 - Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25 +Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.
AB - Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25 +Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.
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U2 - 10.1007/s11011-010-9226-6
DO - 10.1007/s11011-010-9226-6
M3 - Article
C2 - 21082336
AN - SCOPUS:79955083477
VL - 26
SP - 87
EP - 90
JO - Metabolic Brain Disease
JF - Metabolic Brain Disease
SN - 0885-7490
IS - 1
ER -