CD5-negative B-cell chronic lymphocytic leukemia (B-CLL) associated with massive splenomegaly and without lymphadenopathy

T. Yamada, H. Ninomiya, Takahiko Horiuchi, K. Takada, T. Hato, K. Yamauchi, M. Yasukawa, S. Fujita

Research output: Contribution to journalArticle

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Abstract

A 39-year-old male was referred to our hospital in June, 1993, because of leukocytosis. Physical examinations showed massive splenomegaly without any lymphadenopathy. The white blood cell count was 13,800/microliters with 87% morphologically mature lymphocytes. Bone marrow aspirate revealed hypercellularity with 67% lymphocytes morphologically similar to peripheral lymphocytes. The lymphocytes displayed monoclonal rearrangements of immunoglobulin genes and the phenotype of CD5-CD19+CD20+ CD21+ and Smlg+. Splenectomy was effective against neutropenia and thromboytopenia. The clinical and laboratory findings of this case were unusual compared to those of typical B-CLL in massive splenomegaly, no lymphadenopathy and CD5-phenotype, suggesting the heterogeneity of B-CLL.

Original languageEnglish
Pages (from-to)1230-1232
Number of pages3
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume36
Issue number10
Publication statusPublished - Jan 1 1995
Externally publishedYes

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Splenomegaly
B-Cell Chronic Lymphocytic Leukemia
Lymphocytes
Phenotype
Immunoglobulin Genes
Leukocytosis
Splenectomy
Neutropenia
Leukocyte Count
Physical Examination
Bone Marrow
Lymphadenopathy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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CD5-negative B-cell chronic lymphocytic leukemia (B-CLL) associated with massive splenomegaly and without lymphadenopathy. / Yamada, T.; Ninomiya, H.; Horiuchi, Takahiko; Takada, K.; Hato, T.; Yamauchi, K.; Yasukawa, M.; Fujita, S.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 36, No. 10, 01.01.1995, p. 1230-1232.

Research output: Contribution to journalArticle

Yamada, T. ; Ninomiya, H. ; Horiuchi, Takahiko ; Takada, K. ; Hato, T. ; Yamauchi, K. ; Yasukawa, M. ; Fujita, S. / CD5-negative B-cell chronic lymphocytic leukemia (B-CLL) associated with massive splenomegaly and without lymphadenopathy. In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 1995 ; Vol. 36, No. 10. pp. 1230-1232.
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AU - Takada, K.

AU - Hato, T.

AU - Yamauchi, K.

AU - Yasukawa, M.

AU - Fujita, S.

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