@inbook{e9386e5e4e064569aaab213c3644c448,
title = "Cell death or survival against oxidative stress",
abstract = "Peroxisomes contain anabolic and catabolic enzymes including oxidases that produce hydrogen peroxide as a by-product. Peroxisomes also contain catalase to metabolize hydrogen peroxide. It has been recognized that catalase is localized to cytosol in addition to peroxisomes. A recent study has revealed that loss of VDAC2 shifts localization of BAK, a pro-apoptotic member of Bcl-2 family, from mitochondria to peroxisomes and cytosol, thereby leading to release of peroxisomal matrix proteins including catalase to the cytosol. A subset of BAK is localized to peroxisomes even in wild-type cells, regulating peroxisomal membrane permeability and catalase localization. The cytosolic catalase potentially acts as an antioxidant to eliminate extra-peroxisomal hydrogen peroxide.",
author = "Non Miyata and Kanji Okumoto and Yukio Fujiki",
year = "2018",
month = jan,
day = "1",
doi = "10.1007/978-981-13-2233-4_20",
language = "English",
series = "Subcellular Biochemistry",
publisher = "Springer New York",
pages = "463--471",
booktitle = "Subcellular Biochemistry",
address = "United States",
}