Abstract
Peroxisomes contain anabolic and catabolic enzymes including oxidases that produce hydrogen peroxide as a by-product. Peroxisomes also contain catalase to metabolize hydrogen peroxide. It has been recognized that catalase is localized to cytosol in addition to peroxisomes. A recent study has revealed that loss of VDAC2 shifts localization of BAK, a pro-apoptotic member of Bcl-2 family, from mitochondria to peroxisomes and cytosol, thereby leading to release of peroxisomal matrix proteins including catalase to the cytosol. A subset of BAK is localized to peroxisomes even in wild-type cells, regulating peroxisomal membrane permeability and catalase localization. The cytosolic catalase potentially acts as an antioxidant to eliminate extra-peroxisomal hydrogen peroxide.
| Original language | English |
|---|---|
| Title of host publication | Subcellular Biochemistry |
| Publisher | Springer New York |
| Pages | 463-471 |
| Number of pages | 9 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
Publication series
| Name | Subcellular Biochemistry |
|---|---|
| Volume | 89 |
| ISSN (Print) | 0306-0225 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology
- Cancer Research
Cite this
Cell death or survival against oxidative stress. / Miyata, Non; Okumoto, Kanji; Fujiki, Yukio.
Subcellular Biochemistry. Springer New York, 2018. p. 463-471 (Subcellular Biochemistry; Vol. 89).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Cell death or survival against oxidative stress
AU - Miyata, Non
AU - Okumoto, Kanji
AU - Fujiki, Yukio
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Peroxisomes contain anabolic and catabolic enzymes including oxidases that produce hydrogen peroxide as a by-product. Peroxisomes also contain catalase to metabolize hydrogen peroxide. It has been recognized that catalase is localized to cytosol in addition to peroxisomes. A recent study has revealed that loss of VDAC2 shifts localization of BAK, a pro-apoptotic member of Bcl-2 family, from mitochondria to peroxisomes and cytosol, thereby leading to release of peroxisomal matrix proteins including catalase to the cytosol. A subset of BAK is localized to peroxisomes even in wild-type cells, regulating peroxisomal membrane permeability and catalase localization. The cytosolic catalase potentially acts as an antioxidant to eliminate extra-peroxisomal hydrogen peroxide.
AB - Peroxisomes contain anabolic and catabolic enzymes including oxidases that produce hydrogen peroxide as a by-product. Peroxisomes also contain catalase to metabolize hydrogen peroxide. It has been recognized that catalase is localized to cytosol in addition to peroxisomes. A recent study has revealed that loss of VDAC2 shifts localization of BAK, a pro-apoptotic member of Bcl-2 family, from mitochondria to peroxisomes and cytosol, thereby leading to release of peroxisomal matrix proteins including catalase to the cytosol. A subset of BAK is localized to peroxisomes even in wild-type cells, regulating peroxisomal membrane permeability and catalase localization. The cytosolic catalase potentially acts as an antioxidant to eliminate extra-peroxisomal hydrogen peroxide.
UR - http://www.scopus.com/inward/record.url?scp=85055621092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055621092&partnerID=8YFLogxK
U2 - 10.1007/978-981-13-2233-4_20
DO - 10.1007/978-981-13-2233-4_20
M3 - Chapter
C2 - 30378036
AN - SCOPUS:85055621092
T3 - Subcellular Biochemistry
SP - 463
EP - 471
BT - Subcellular Biochemistry
PB - Springer New York
ER -