Cell death or survival against oxidative stress

Non Miyata, Kanji Okumoto, Yukio Fujiki

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Peroxisomes contain anabolic and catabolic enzymes including oxidases that produce hydrogen peroxide as a by-product. Peroxisomes also contain catalase to metabolize hydrogen peroxide. It has been recognized that catalase is localized to cytosol in addition to peroxisomes. A recent study has revealed that loss of VDAC2 shifts localization of BAK, a pro-apoptotic member of Bcl-2 family, from mitochondria to peroxisomes and cytosol, thereby leading to release of peroxisomal matrix proteins including catalase to the cytosol. A subset of BAK is localized to peroxisomes even in wild-type cells, regulating peroxisomal membrane permeability and catalase localization. The cytosolic catalase potentially acts as an antioxidant to eliminate extra-peroxisomal hydrogen peroxide.

Original languageEnglish
Title of host publicationSubcellular Biochemistry
PublisherSpringer New York
Pages463-471
Number of pages9
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameSubcellular Biochemistry
Volume89
ISSN (Print)0306-0225

Fingerprint

Peroxisomes
Oxidative stress
Cell death
Catalase
Cell Survival
Oxidative Stress
Cell Death
Cytosol
Hydrogen Peroxide
Mitochondria
Byproducts
Permeability
Oxidoreductases
Antioxidants
Membranes
Enzymes
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research

Cite this

Miyata, N., Okumoto, K., & Fujiki, Y. (2018). Cell death or survival against oxidative stress. In Subcellular Biochemistry (pp. 463-471). (Subcellular Biochemistry; Vol. 89). Springer New York. https://doi.org/10.1007/978-981-13-2233-4_20

Cell death or survival against oxidative stress. / Miyata, Non; Okumoto, Kanji; Fujiki, Yukio.

Subcellular Biochemistry. Springer New York, 2018. p. 463-471 (Subcellular Biochemistry; Vol. 89).

Research output: Chapter in Book/Report/Conference proceedingChapter

Miyata, N, Okumoto, K & Fujiki, Y 2018, Cell death or survival against oxidative stress. in Subcellular Biochemistry. Subcellular Biochemistry, vol. 89, Springer New York, pp. 463-471. https://doi.org/10.1007/978-981-13-2233-4_20
Miyata N, Okumoto K, Fujiki Y. Cell death or survival against oxidative stress. In Subcellular Biochemistry. Springer New York. 2018. p. 463-471. (Subcellular Biochemistry). https://doi.org/10.1007/978-981-13-2233-4_20
Miyata, Non ; Okumoto, Kanji ; Fujiki, Yukio. / Cell death or survival against oxidative stress. Subcellular Biochemistry. Springer New York, 2018. pp. 463-471 (Subcellular Biochemistry).
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