Cell death or survival against oxidative stress

Non Miyata, Kanji Okumoto, Yukio Fujiki

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Peroxisomes contain anabolic and catabolic enzymes including oxidases that produce hydrogen peroxide as a by-product. Peroxisomes also contain catalase to metabolize hydrogen peroxide. It has been recognized that catalase is localized to cytosol in addition to peroxisomes. A recent study has revealed that loss of VDAC2 shifts localization of BAK, a pro-apoptotic member of Bcl-2 family, from mitochondria to peroxisomes and cytosol, thereby leading to release of peroxisomal matrix proteins including catalase to the cytosol. A subset of BAK is localized to peroxisomes even in wild-type cells, regulating peroxisomal membrane permeability and catalase localization. The cytosolic catalase potentially acts as an antioxidant to eliminate extra-peroxisomal hydrogen peroxide.

Original languageEnglish
Title of host publicationSubcellular Biochemistry
PublisherSpringer New York
Pages463-471
Number of pages9
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameSubcellular Biochemistry
Volume89
ISSN (Print)0306-0225

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research

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