Cell deformability measurements for single cancer cells by ionic current in microfluidic devices

Mamiko Sano, Noritada Kaji, Takao Yasui, Yoshinobu Baba

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To realize high-throughput, easy to use, and high-accuracy cell deformability measurements, we have developed ionic current detection system combined with constriction structure inside microchannel. In this system, when cells are clogged in constriction, the resistivity of detection area increases and the current decreases by ionic current blockade. We successfully detected unique signal shapes derived from cell deformability during the cell passage at the constriction. The signal shapes might provide an information on cell deformation and nucleus position inside a cell.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages455-457
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - Jan 1 2015
Externally publishedYes
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: Oct 25 2015Oct 29 2015

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period10/25/1510/29/15

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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  • Cite this

    Sano, M., Kaji, N., Yasui, T., & Baba, Y. (2015). Cell deformability measurements for single cancer cells by ionic current in microfluidic devices. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 455-457). (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.