Cell fate modification toward the hepatic lineage by extrinsic factors

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The lineage of a somatic cell can be altered by targeting its signaling networks with small molecules and/or genetically altering the expression of key transcription factors. Depending on the combination of factors, fibroblasts can be fully reprogrammed into induced pluripotent stem (iPS) cells or directly converted into specific cell lineages, bypassing the pluripotent state. The generation of defined target cells will enormously benefit patients who require cell transplantation therapy. In the decade, since iPS cells were first generated, many cell types have been induced fromfibroblasts by direct conversion, including hepatocytes. Converted hepatocytelike cells have been shown to repopulate liver tissues after transplantation in mouse liver disease models, suggesting promise for future application in humans.Thus, to realize safe and efficient cell transplantation therapy, various methods for generating hepatocyte-like cells are being developed. In this review, we summarize the current methods for the generation of hepatocyte-like cells via cell fate modification using extrinsic factors.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalJournal of Biochemistry
Volume162
Issue number1
DOIs
Publication statusPublished - Jul 1 2017

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Stem cells
Liver
Hepatocytes
Induced Pluripotent Stem Cells
Fibroblasts
Cell Transplantation
Cell- and Tissue-Based Therapy
Transcription Factors
Tissue
Molecules
Tissue Transplantation
Cell Lineage
Liver Transplantation
Liver Diseases

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Cell fate modification toward the hepatic lineage by extrinsic factors. / Kawamata, Masaki; Suzuki, Atsushi.

In: Journal of Biochemistry, Vol. 162, No. 1, 01.07.2017, p. 11-16.

Research output: Contribution to journalReview article

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