The proliferative activity of intracerebrally implanted rat glioma C6 (RG-C6) tumors in rats was exam ined by means of 3H-thymidine autoradiography and measurement of bromodeoxyuridine (BrdU) uptake. The effect of intracarotid hyperosmolar mannitol on the cell kinetics of the RG-C6 tumors was studied by the latter method. The labeling index (LI) and distribution of 3H-thymidine-labeled cells were identical to those of the BrdU-labeled cells. The LIs of BrdU-labeled cells were not altered by in tracarotid mannitol injection. The influence of intracarotid hyperosmolar mannitol infusion not only on brain tumors but also on normal brain tissue is discussed.
All Science Journal Classification (ASJC) codes
- Clinical Neurology