Cell to cell adhesion systems in Xenopus laevis, the South African clawed toad II: Monoclonal antibody against a novel Ca2+-dependent cell-cell adhesion glycoprotein on amphibian cells

K. Nomura, T. Tajima, H. Nomura, H. Shiraishi, M. Uchida, K. Yamana

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We isolated a mouse monoclonal antibody that disrupts Ca2+-dependent cell-cell adhesion of amphibian (Xenopus laevis) cells. When added to culture medium, the monoclonal antibody completely disrupted cell-cell adhesion of amphibian cells in monolayer culture and specifically inhibited Ca2+-dependent cell-cell adhesion of dissociated cells in reaggregation experiments. The monoclonal antibody recognized a 140 kDa cell surface glycoprotein antigenically different from the previously reported Ca2+-dependent cell-cell adhesion molecules (cadherins).

Original languageEnglish
Pages (from-to)207-212
Number of pages6
JournalCell Differentiation
Volume23
Issue number3
DOIs
Publication statusPublished - Apr 1988

All Science Journal Classification (ASJC) codes

  • Developmental Biology

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