TY - JOUR
T1 - Cell to cell adhesion systems in Xenopus laevis, the South African clawed toad II
T2 - Monoclonal antibody against a novel Ca2+-dependent cell-cell adhesion glycoprotein on amphibian cells
AU - Nomura, K.
AU - Tajima, T.
AU - Nomura, H.
AU - Shiraishi, H.
AU - Uchida, M.
AU - Yamana, K.
N1 - Funding Information:
We thank Dr. R. Clothier (University of Nottingham) for the generous gift of X69 cells, Prof. M. Takeichi (Kyoto University) for the gift of monoclonal antibodies against cadherins and for interest in our work together with helpful discussions, and M. Ohara (Kyushu Univ.) for comments on the manuscript. This work was supported by Grant-in-Aid from the Ministry of Education, Science and Culture, Japan to one of the authors (K.N.).
PY - 1988/4
Y1 - 1988/4
N2 - We isolated a mouse monoclonal antibody that disrupts Ca2+-dependent cell-cell adhesion of amphibian (Xenopus laevis) cells. When added to culture medium, the monoclonal antibody completely disrupted cell-cell adhesion of amphibian cells in monolayer culture and specifically inhibited Ca2+-dependent cell-cell adhesion of dissociated cells in reaggregation experiments. The monoclonal antibody recognized a 140 kDa cell surface glycoprotein antigenically different from the previously reported Ca2+-dependent cell-cell adhesion molecules (cadherins).
AB - We isolated a mouse monoclonal antibody that disrupts Ca2+-dependent cell-cell adhesion of amphibian (Xenopus laevis) cells. When added to culture medium, the monoclonal antibody completely disrupted cell-cell adhesion of amphibian cells in monolayer culture and specifically inhibited Ca2+-dependent cell-cell adhesion of dissociated cells in reaggregation experiments. The monoclonal antibody recognized a 140 kDa cell surface glycoprotein antigenically different from the previously reported Ca2+-dependent cell-cell adhesion molecules (cadherins).
UR - http://www.scopus.com/inward/record.url?scp=0023882818&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023882818&partnerID=8YFLogxK
U2 - 10.1016/0045-6039(88)90073-5
DO - 10.1016/0045-6039(88)90073-5
M3 - Article
C2 - 3378270
AN - SCOPUS:0023882818
VL - 23
SP - 207
EP - 212
JO - Cell Differentiation and Development
JF - Cell Differentiation and Development
SN - 0925-4773
IS - 3
ER -