Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation

Yoshihiro Kano, Hideshi Ishii, Masamitsu Konno, Makoto Yamasaki, Hiroshi Miyata, Shimpei Nishikawa, Atsushi Hamabe, Hisataka Ogawa, Hidekazu Takahashi, Katsuya Ohta, Shinichiro Hasegawa, Kouji Tanaka, Takahito Fukusumi, Masahisa Otsuka, Koichi Kawamoto, Naotsugu Haraguchi, Rika Fujimoto, Masaharu Isobe, Yasuhiko Tomita, Nariaki MatsuuraShuji Takiguchi, Masaki Mori, Yuichiro Doki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Secondary solid tumors that occur after hematopoietic stem cell transplantation (HSCT) are late complications of HSCT. Previously, secondary solid tumors were considered to be recipient-derived cells because transplanted cells do not contain epithelial cells. Recently, however, not only donor-derived epithelial cells but also donor-derived secondary solid tumors have also been reported in mice and humans. It means that circulating bone marrow-derived stem cells (BMDCs) including hematopoietic stem cells include the stem cells of many tissue types and the precancerous cells of many solid tumors. In most reports of donor-derived secondary solid tumors, however, tumors contained a low proportion of BMDC-derived epithelial cells in mixed solid tumor tissues. To our knowledge, there are only five known cases of completely donor-derived tumor tissues, i.e., four oral SCCs and a pharyngeal SCC. In this study, we analyzed five human clinical samples of solid tumors, i.e., two esophageal squamous cell carcinomas (SCCs), two oral SCCs and a tongue carcinoma. In the oral and tongue, completely donor-derived tissues were not observed, but in esophagus a completely donor-derived esophageal epidermis and SCC were observed for the first time. In addition, in another esophageal SCC patient, a completely donor-derived dysplasia region of esophageal epidermis was observed near recipient-derived SCC. This study suggests that BMDC-derived cells include the stem cells of esophageal epidermis and the precancerous cells of esophageal SCC and can differentiate into esophageal epithelium and esophageal SCC.

Original languageEnglish
Pages (from-to)443-450
Number of pages8
JournalInternational journal of oncology
Volume44
Issue number2
DOIs
Publication statusPublished - Feb 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Kano, Y., Ishii, H., Konno, M., Yamasaki, M., Miyata, H., Nishikawa, S., Hamabe, A., Ogawa, H., Takahashi, H., Ohta, K., Hasegawa, S., Tanaka, K., Fukusumi, T., Otsuka, M., Kawamoto, K., Haraguchi, N., Fujimoto, R., Isobe, M., Tomita, Y., ... Doki, Y. (2014). Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation. International journal of oncology, 44(2), 443-450. https://doi.org/10.3892/ijo.2013.2206