Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus

George L. King; Teruo Shiba; Javier Oliver; Toyoshi Inoguchi; Sven Erik Bursell

doi:10.1146/annurev.med.45.1.179

Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus

George L. King, Teruo Shiba, Javier Oliver, Toyoshi Inoguchi, Sven Erik Bursell

Research output: Contribution to journal › Review article › peer-review

118 Citations (Scopus)

Abstract

Diabetic vascular complications affect both micro- and macrovasculature, primarily in the retina, renal glomeruli, and multiple sites in the macrovessels. This review presents a summary of the abnormal function found in vivo and in cultured vascular cells exposed to elevated levels of glucose. We also discuss the various biochemical hypotheses that have been proposed to explain the adverse effects of hyperglycemia on vascular cells.

Original language	English
Pages (from-to)	179-188
Number of pages	10
Journal	Annual review of medicine
Volume	45
DOIs	https://doi.org/10.1146/annurev.med.45.1.179
Publication status	Published - 1994

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Diabetic vascular complications affect both micro- and macrovasculature, primarily in the retina, renal glomeruli, and multiple sites in the macrovessels. This review presents a summary of the abnormal function found in vivo and in cultured vascular cells exposed to elevated levels of glucose. We also discuss the various biochemical hypotheses that have been proposed to explain the adverse effects of hyperglycemia on vascular cells.",

author = "King, {George L.} and Teruo Shiba and Javier Oliver and Toyoshi Inoguchi and Bursell, {Sven Erik}",

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AU - Oliver, Javier

AU - Inoguchi, Toyoshi

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