TY - JOUR
T1 - Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus
AU - King, George L.
AU - Shiba, Teruo
AU - Oliver, Javier
AU - Inoguchi, Toyoshi
AU - Bursell, Sven Erik
PY - 1994
Y1 - 1994
N2 - Diabetic vascular complications affect both micro- and macrovasculature, primarily in the retina, renal glomeruli, and multiple sites in the macrovessels. This review presents a summary of the abnormal function found in vivo and in cultured vascular cells exposed to elevated levels of glucose. We also discuss the various biochemical hypotheses that have been proposed to explain the adverse effects of hyperglycemia on vascular cells.
AB - Diabetic vascular complications affect both micro- and macrovasculature, primarily in the retina, renal glomeruli, and multiple sites in the macrovessels. This review presents a summary of the abnormal function found in vivo and in cultured vascular cells exposed to elevated levels of glucose. We also discuss the various biochemical hypotheses that have been proposed to explain the adverse effects of hyperglycemia on vascular cells.
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U2 - 10.1146/annurev.med.45.1.179
DO - 10.1146/annurev.med.45.1.179
M3 - Review article
C2 - 8198375
AN - SCOPUS:0028321899
VL - 45
SP - 179
EP - 188
JO - Annual Review of Medicine
JF - Annual Review of Medicine
SN - 0066-4219
ER -
