Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus

George L. King, Teruo Shiba, Javier Oliver, Toyoshi Inoguchi, Sven Erik Bursell

    Research output: Contribution to journalReview article

    115 Citations (Scopus)


    Diabetic vascular complications affect both micro- and macrovasculature, primarily in the retina, renal glomeruli, and multiple sites in the macrovessels. This review presents a summary of the abnormal function found in vivo and in cultured vascular cells exposed to elevated levels of glucose. We also discuss the various biochemical hypotheses that have been proposed to explain the adverse effects of hyperglycemia on vascular cells.

    Original languageEnglish
    Pages (from-to)179-188
    Number of pages10
    JournalAnnual review of medicine
    Publication statusPublished - May 25 1994


    All Science Journal Classification (ASJC) codes

    • Biochemistry, Genetics and Molecular Biology(all)

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