Cellular behaviors on polymeric scaffolds with 2D-patterned mechanical properties

Shinichiro Shimomura, Hisao Matsuno, Yohei Kinoshita, Satoshi Fujimura, Keiji Tanaka

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    We propose a novel concept for cellular scaffolds with 2D-patterned mechanical properties. Thin films of glassy polystyrene (PS) with thicknesses ranging from 100 nm to 1 μm were prepared on epoxy resin-based line and space (L&S) patterned substrates. Although the outermost surface of PS on the L- and S-regions was sufficiently flat at the same level, the mechanical responses differed depending on the presence of the underlying resin foundation. The initial cell adhesion and spreading and the proliferation on the scaffolds were affected by the 2D-patterned mechanical properties, that is, cellular behavior was suppressed on mechanically unstable S-regions.

    Original languageEnglish
    Pages (from-to)737-743
    Number of pages7
    JournalPolymer Journal
    Volume50
    Issue number8
    DOIs
    Publication statusPublished - Aug 1 2018

    All Science Journal Classification (ASJC) codes

    • Polymers and Plastics
    • Materials Chemistry

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