Cellular distribution of αB-crystallin in non-lenticular tissues

T. Iwaki, A. Kume-Iwaki, J. E. Goldman

Research output: Contribution to journalArticle

254 Citations (Scopus)

Abstract

αB-Crystallin is a subunit of α-crystallin, a major protein component of the vertebrate lens. Recently, its expression in various extra-lenticular tissues has been demonstrated by both Western and Northern blotting. In this study, the cellular distribution of αB-crystallin in rat organs was examined in detail using immunohistochemistry. Positive reactions were observed in lens, iris, heart, skeletal muscle (type 1 and type 2A fibers), striated muscle in skin and esophagus, Henle's loop and medullary collecting duct of the kidney, Schwann cells of peripheral nerves, glia of the central nervous system, and decidual cells of the placenta. A close correlation with markers of oxidative activity suggests that αB-crystallin is expressed in cells that have high levels of oxidative function.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalJournal of Histochemistry and Cytochemistry
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 1 1990

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Crystallins
Lenses
Collecting Kidney Tubules
Loop of Henle
Striated Muscle
Schwann Cells
Iris
Peripheral Nerves
Neuroglia
Northern Blotting
Placenta
Esophagus
Vertebrates
Myocardium
Skeletal Muscle
Central Nervous System
Western Blotting
Immunohistochemistry
Skin
Proteins

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Histology

Cite this

Cellular distribution of αB-crystallin in non-lenticular tissues. / Iwaki, T.; Kume-Iwaki, A.; Goldman, J. E.

In: Journal of Histochemistry and Cytochemistry, Vol. 38, No. 1, 01.01.1990, p. 31-39.

Research output: Contribution to journalArticle

Iwaki, T. ; Kume-Iwaki, A. ; Goldman, J. E. / Cellular distribution of αB-crystallin in non-lenticular tissues. In: Journal of Histochemistry and Cytochemistry. 1990 ; Vol. 38, No. 1. pp. 31-39.
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