Cellular distribution of αB-crystallin in non-lenticular tissues

T. Iwaki, A. Kume-Iwaki, J. E. Goldman

Research output: Contribution to journalArticle

260 Citations (Scopus)

Abstract

αB-Crystallin is a subunit of α-crystallin, a major protein component of the vertebrate lens. Recently, its expression in various extra-lenticular tissues has been demonstrated by both Western and Northern blotting. In this study, the cellular distribution of αB-crystallin in rat organs was examined in detail using immunohistochemistry. Positive reactions were observed in lens, iris, heart, skeletal muscle (type 1 and type 2A fibers), striated muscle in skin and esophagus, Henle's loop and medullary collecting duct of the kidney, Schwann cells of peripheral nerves, glia of the central nervous system, and decidual cells of the placenta. A close correlation with markers of oxidative activity suggests that αB-crystallin is expressed in cells that have high levels of oxidative function.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalJournal of Histochemistry and Cytochemistry
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 1 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Histology

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