Cellular force measurement using a nanometric-probe-integrated microfluidic chip with a displacement reduction mechanism

Shinya Sakuma, Fumihito Arai

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

This paper presents noncontact nanometric positioning of a probe tip with high output force in a microfluidic chip. To measure cellular force in a microfluidic chip on the basis of cell deformation, we employed an on-chip probe with a magnetic drive method with actuation on the order of millinewtons. A reduction mechanism was proposed to realize nanometric resolution for positioning the probe tip. This mechanism utilizes a combination of springs with different stiffness levels and is driven by magnetic force. The performance of the prototype device was examined and results indicated that, as a measure of repetitive positioning accuracy, standard deviation of probe tip displacement was under 0.18 μm. Deformation was successfully measured for an oocyte on the order of 0.1 mN, demonstrating, as a consequence, nanometric order noncontact actuation of the on-chip probe with high output force. Using this on-chip probe, cellular force measurement was achieved for the microfluidic chip.

Original languageEnglish
Pages (from-to)277-284
Number of pages8
JournalJournal of Robotics and Mechatronics
Volume25
Issue number2
DOIs
Publication statusPublished - Apr 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Computer Science(all)
  • Electrical and Electronic Engineering

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