Cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Kazuo Fujihara, Yasuto Itoyama, Feng Yu, Chiharu Kubo, Ikuo Goto

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

To investigate the cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we studied the cytotoxic T lymphocytes (CTL) activity against an HTLV-I infected human T cell line (MT-2) and the natural killer (NK) cell activity in 15 HAM patients, 6 HTLV-I carriers, and 15 controls. The activity of CTL against MT-2 cells was found to be significantly elevated in HAM compared with that in the controls. This cytotoxicity in HAM was higher than in HTLV-I carriers, although the difference was not statistically significant. There was an HLA class I restriction in this CTL activity against MT-2 cells in HAM. On the other hand, NK cell activity was significantly lower in HAM than in controls. Cold target inhibition studies suggested that NK cells could not lyse MT-2 cells effectively. There was a positive correlation between the CTL activity against MT-2 cells and the serum antibody titers to HTLV-I in HAM.

Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalJournal of the Neurological Sciences
Volume105
Issue number1
DOIs
Publication statusPublished - Jan 1 1991

Fingerprint

Tropical Spastic Paraparesis
Human T-lymphotropic virus 1
Cytotoxic T-Lymphocytes
T-Lymphocytes
Natural Killer Cells
Cell Line
Antibodies
Serum

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). / Fujihara, Kazuo; Itoyama, Yasuto; Yu, Feng; Kubo, Chiharu; Goto, Ikuo.

In: Journal of the Neurological Sciences, Vol. 105, No. 1, 01.01.1991, p. 99-107.

Research output: Contribution to journalArticle

@article{fb6476ab6f674c51ba78ddd4d9d5a1e8,
title = "Cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP)",
abstract = "To investigate the cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we studied the cytotoxic T lymphocytes (CTL) activity against an HTLV-I infected human T cell line (MT-2) and the natural killer (NK) cell activity in 15 HAM patients, 6 HTLV-I carriers, and 15 controls. The activity of CTL against MT-2 cells was found to be significantly elevated in HAM compared with that in the controls. This cytotoxicity in HAM was higher than in HTLV-I carriers, although the difference was not statistically significant. There was an HLA class I restriction in this CTL activity against MT-2 cells in HAM. On the other hand, NK cell activity was significantly lower in HAM than in controls. Cold target inhibition studies suggested that NK cells could not lyse MT-2 cells effectively. There was a positive correlation between the CTL activity against MT-2 cells and the serum antibody titers to HTLV-I in HAM.",
author = "Kazuo Fujihara and Yasuto Itoyama and Feng Yu and Chiharu Kubo and Ikuo Goto",
year = "1991",
month = "1",
day = "1",
doi = "10.1016/0022-510X(91)90125-Q",
language = "English",
volume = "105",
pages = "99--107",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP)

AU - Fujihara, Kazuo

AU - Itoyama, Yasuto

AU - Yu, Feng

AU - Kubo, Chiharu

AU - Goto, Ikuo

PY - 1991/1/1

Y1 - 1991/1/1

N2 - To investigate the cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we studied the cytotoxic T lymphocytes (CTL) activity against an HTLV-I infected human T cell line (MT-2) and the natural killer (NK) cell activity in 15 HAM patients, 6 HTLV-I carriers, and 15 controls. The activity of CTL against MT-2 cells was found to be significantly elevated in HAM compared with that in the controls. This cytotoxicity in HAM was higher than in HTLV-I carriers, although the difference was not statistically significant. There was an HLA class I restriction in this CTL activity against MT-2 cells in HAM. On the other hand, NK cell activity was significantly lower in HAM than in controls. Cold target inhibition studies suggested that NK cells could not lyse MT-2 cells effectively. There was a positive correlation between the CTL activity against MT-2 cells and the serum antibody titers to HTLV-I in HAM.

AB - To investigate the cellular immune surveillance against HTLV-I infected T lymphocytes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we studied the cytotoxic T lymphocytes (CTL) activity against an HTLV-I infected human T cell line (MT-2) and the natural killer (NK) cell activity in 15 HAM patients, 6 HTLV-I carriers, and 15 controls. The activity of CTL against MT-2 cells was found to be significantly elevated in HAM compared with that in the controls. This cytotoxicity in HAM was higher than in HTLV-I carriers, although the difference was not statistically significant. There was an HLA class I restriction in this CTL activity against MT-2 cells in HAM. On the other hand, NK cell activity was significantly lower in HAM than in controls. Cold target inhibition studies suggested that NK cells could not lyse MT-2 cells effectively. There was a positive correlation between the CTL activity against MT-2 cells and the serum antibody titers to HTLV-I in HAM.

UR - http://www.scopus.com/inward/record.url?scp=0025818101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025818101&partnerID=8YFLogxK

U2 - 10.1016/0022-510X(91)90125-Q

DO - 10.1016/0022-510X(91)90125-Q

M3 - Article

C2 - 1795176

AN - SCOPUS:0025818101

VL - 105

SP - 99

EP - 107

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1

ER -