Cellular immunoregulation in atopic dermatitis--hyperresponsiveness to interleukin-4 and hyporesponsiveness to interleukin-2

M. Ohtsuki, F. Ogata, M. Furue, Y. Ishibashi

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Abstract

We examined the responsiveness to Interleukin-4 (IL-4) and Interleukin-2 (IL-2) of peripheral blood lymphocytes from patients with atopic dermatitis (AD) and non-AD controls. The IL-4 responsiveness of the AD patients was found to be higher than that of the non-AD controls. In contrast, the IL-2 responsiveness of the AD patients was relatively lower than that of the non-AD controls. When IL-4/IL-2 responsiveness ratio was compared, the IL-4/IL-2 responsiveness ratio of the AD patients (54.1 +/- 18.5) was significantly higher than that of the non-AD controls (24.8 +/- 9.9, p less than 0.001). The high IL-4/IL-2 responsiveness ratio found in the AD patients may possibly be related to the pathogenesis of AD.

Original languageEnglish
Pages (from-to)1169-1172
Number of pages4
JournalJapanese Journal of Allergology
Volume38
Issue number10
Publication statusPublished - Oct 1 1989
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

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