Cellular mechanical imepedance measurement by robot integrated microfluidic chip with width tunable microchannel

Shinya Sakuma, Makoto Kaneko, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents the on-chip cellular mechanical impedance measurement by OCAIN (On-Chip Impedance ANalyzer). Robochip(robot integrated microfluidic chip) is installed in OCIAN as a disposable microfluidic component integrated with robotic sensing unit. For the high throughput sensing of cellular specimens, they are flown in the microchannel of Robochip and continuous multi-parameter sensing is carried out. For the cellular mechanical impedance measurement, a pair of width tunable wall and force sensor is integrated at the sensing area. One side of the wall is actuated in non-contact by the magnetic force, therefore, the wall is powerful enough to collapse a rigid cell and Robochip is disconnected with the outer magnetic driving system. These are quite advantageous, however, it was quite difficult to improve the position accuracy of the magnetically driven components in the chip. Here we succeeded in nanometric order tuning of the tunable wall width by the displacement reduction mechanism which was previously proposed by our group. Then we achieved cellular impedance measurement of flowing cells in the microchannel by nanometric tuning of the wall.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages692-694
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012
Externally publishedYes
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: Oct 28 2012Nov 1 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period10/28/1211/1/12

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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