TY - JOUR
T1 - Cellulose-based molecularly imprinted red-blood-cell-like microparticles for the selective capture of cortisol
AU - Hayashi, Koichiro
AU - Hayashi, Hikaru
AU - Yamada, Shota
AU - Sakamoto, Wataru
AU - Yogo, Toshinobu
N1 - Funding Information:
We are grateful to the Center for Animal Research and Education (CARE) and the Technical Center at Nagoya University. This work was supported by Japan Society for the Promotion of Science (Grant-in-Aid for Sientific Research (A), 15H02296). The authors declare that they have no competing interests.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Magnetite-nanoparticle-containing red-blood-cell-like-microparticles (M-RBC-MPs) with a selective ability for trapping cortisol (COR) were synthesized by an electrospray technique of a molecularly imprinted ethyl(hydroxyethyl) cellulose (EHEC)-based precursor. The as-synthezied M-RBC-MPs were ∼3-μm-disks with a dent. M-RBC-MPs contained magnetite nanoparticles below 15 nm in diameter, which exhibited magnetization and no room-temperature coercivity. The molecularly imprinted M-RBC-MPs (MI-M-RBC-MPs) passed through pores less than their diameter. The MI-M-RBC-MPs selectively trapped COR from a solution containing molecules similar to COR, whereas non-imprinted M-RBC-MPs did not trap COR. Furthermore, magnets were used to capture the water-dispersed MI-M-RBC-MPs flowing in a tube. Based on the above results, MI-M-RBC-MPs may selectively trap COR while simultaneously circulating in the blood, followed by their removal from the blood using magnets.
AB - Magnetite-nanoparticle-containing red-blood-cell-like-microparticles (M-RBC-MPs) with a selective ability for trapping cortisol (COR) were synthesized by an electrospray technique of a molecularly imprinted ethyl(hydroxyethyl) cellulose (EHEC)-based precursor. The as-synthezied M-RBC-MPs were ∼3-μm-disks with a dent. M-RBC-MPs contained magnetite nanoparticles below 15 nm in diameter, which exhibited magnetization and no room-temperature coercivity. The molecularly imprinted M-RBC-MPs (MI-M-RBC-MPs) passed through pores less than their diameter. The MI-M-RBC-MPs selectively trapped COR from a solution containing molecules similar to COR, whereas non-imprinted M-RBC-MPs did not trap COR. Furthermore, magnets were used to capture the water-dispersed MI-M-RBC-MPs flowing in a tube. Based on the above results, MI-M-RBC-MPs may selectively trap COR while simultaneously circulating in the blood, followed by their removal from the blood using magnets.
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U2 - 10.1016/j.carbpol.2018.03.095
DO - 10.1016/j.carbpol.2018.03.095
M3 - Article
C2 - 29773369
AN - SCOPUS:85044941363
SN - 0144-8617
VL - 193
SP - 173
EP - 178
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
ER -