TY - JOUR
T1 - Central α-melanocyte-stimulating hormone acts at melanocortin-4 receptor to activate sympathetic nervous system in conscious rabbits
AU - Matsumura, Kiyoshi
AU - Tsuchihashi, Takuya
AU - Abe, Isao
AU - Iida, Mitsuo
PY - 2002/9/6
Y1 - 2002/9/6
N2 - Intracerebroventricular injection of α-melanocyte-stimulating hormone (α-MSH) elicited increases in arterial pressure and renal sympathetic nerve activity in conscious rabbits. Pretreatment with intracerebroventricular injection of agouti-related protein, an endogenous melanocortin-3 and 4 receptor antagonist, prevented cardiovascular and sympathetic responses to α-MSH. Pretreatment with intracerebroventricular injection of JKC-363, a synthetic specific melanocortin-4 receptor antagonist, also prevented cardiovascular and sympathetic responses to α-MSH. In contrast, intravenous α-MSH (1 nmol) failed to cause any cardiovascular responses. These results suggest that intracerebroventricularly administered α-MSH acts at the melanocortin-4 receptor in the brain and activates sympathetic outflow, resulting in an increase in arterial pressure.
AB - Intracerebroventricular injection of α-melanocyte-stimulating hormone (α-MSH) elicited increases in arterial pressure and renal sympathetic nerve activity in conscious rabbits. Pretreatment with intracerebroventricular injection of agouti-related protein, an endogenous melanocortin-3 and 4 receptor antagonist, prevented cardiovascular and sympathetic responses to α-MSH. Pretreatment with intracerebroventricular injection of JKC-363, a synthetic specific melanocortin-4 receptor antagonist, also prevented cardiovascular and sympathetic responses to α-MSH. In contrast, intravenous α-MSH (1 nmol) failed to cause any cardiovascular responses. These results suggest that intracerebroventricularly administered α-MSH acts at the melanocortin-4 receptor in the brain and activates sympathetic outflow, resulting in an increase in arterial pressure.
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U2 - 10.1016/S0006-8993(02)03045-7
DO - 10.1016/S0006-8993(02)03045-7
M3 - Article
C2 - 12383966
AN - SCOPUS:0037032105
VL - 948
SP - 145
EP - 148
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1-2
ER -