Central α-melanocyte-stimulating hormone acts at melanocortin-4 receptor to activate sympathetic nervous system in conscious rabbits

Kiyoshi Matsumura, Takuya Tsuchihashi, Isao Abe, Mitsuo Iida

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Abstract

Intracerebroventricular injection of α-melanocyte-stimulating hormone (α-MSH) elicited increases in arterial pressure and renal sympathetic nerve activity in conscious rabbits. Pretreatment with intracerebroventricular injection of agouti-related protein, an endogenous melanocortin-3 and 4 receptor antagonist, prevented cardiovascular and sympathetic responses to α-MSH. Pretreatment with intracerebroventricular injection of JKC-363, a synthetic specific melanocortin-4 receptor antagonist, also prevented cardiovascular and sympathetic responses to α-MSH. In contrast, intravenous α-MSH (1 nmol) failed to cause any cardiovascular responses. These results suggest that intracerebroventricularly administered α-MSH acts at the melanocortin-4 receptor in the brain and activates sympathetic outflow, resulting in an increase in arterial pressure.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalBrain Research
Volume948
Issue number1-2
DOIs
Publication statusPublished - Sep 6 2002

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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