Central administration of cocaine- and amphetamine-regulated transcript inhibits food intake in chicks

Tetsuya Tachibana, Tomo Takagi, Shozo Tomonaga, Atsushi Ohgushi, Ryuichi Ando, D. Michael Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

The present study was done to clarify whether intracerebroventricular (ICV) injection of cocaine- and amphetamine-regulated transcript (CART) affects feeding in chicks. ICV injection of CART significantly inhibited fasting-induced feeding of broiler chicks. In layer chicks, on the other hand, CART inhibited food intake in birds with ad libitum access to feed but only weakly affected intake of fasted birds. In addition, the ICV injection of CART attenuated neuropeptide Y (NPY)-induced feeding in both broiler and layer chicks. These results indicate that CART is one of the important regulators of feeding in chicks, but the suppressive effect on feeding is somewhat different between strains. Furthermore, the present study also demonstrates that CART interacts with NPY in the central nervous system to regulate feeding in chicks.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalNeuroscience Letters
Volume337
Issue number3
DOIs
Publication statusPublished - Feb 13 2003

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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