TY - JOUR
T1 - Central administration of cocaine- and amphetamine-regulated transcript inhibits food intake in chicks
AU - Tachibana, Tetsuya
AU - Takagi, Tomo
AU - Tomonaga, Shozo
AU - Ohgushi, Atsushi
AU - Ando, Ryuichi
AU - Denbow, D. Michael
AU - Furuse, Mitsuhiro
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan.
PY - 2003/2/13
Y1 - 2003/2/13
N2 - The present study was done to clarify whether intracerebroventricular (ICV) injection of cocaine- and amphetamine-regulated transcript (CART) affects feeding in chicks. ICV injection of CART significantly inhibited fasting-induced feeding of broiler chicks. In layer chicks, on the other hand, CART inhibited food intake in birds with ad libitum access to feed but only weakly affected intake of fasted birds. In addition, the ICV injection of CART attenuated neuropeptide Y (NPY)-induced feeding in both broiler and layer chicks. These results indicate that CART is one of the important regulators of feeding in chicks, but the suppressive effect on feeding is somewhat different between strains. Furthermore, the present study also demonstrates that CART interacts with NPY in the central nervous system to regulate feeding in chicks.
AB - The present study was done to clarify whether intracerebroventricular (ICV) injection of cocaine- and amphetamine-regulated transcript (CART) affects feeding in chicks. ICV injection of CART significantly inhibited fasting-induced feeding of broiler chicks. In layer chicks, on the other hand, CART inhibited food intake in birds with ad libitum access to feed but only weakly affected intake of fasted birds. In addition, the ICV injection of CART attenuated neuropeptide Y (NPY)-induced feeding in both broiler and layer chicks. These results indicate that CART is one of the important regulators of feeding in chicks, but the suppressive effect on feeding is somewhat different between strains. Furthermore, the present study also demonstrates that CART interacts with NPY in the central nervous system to regulate feeding in chicks.
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U2 - 10.1016/S0304-3940(02)01321-6
DO - 10.1016/S0304-3940(02)01321-6
M3 - Article
C2 - 12536041
AN - SCOPUS:0037434469
SN - 0304-3940
VL - 337
SP - 131
EP - 134
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -