Central administration of interferon-α enhances rat sympathetic nerve activity to the spleen

Toshihiko Katafuchi, Tetsuro Hori, Sachiko Take

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Intracerebroventricular injection of recombinant human interferon-α (IFN-α) in a dose of 1 × 104 U, but not 3 × 103 U, produced a long-lasting (at least for 60 min) increase (2.5-5 times the preinjection level) in the electrical activity of splenic sympathetic nerve filaments in urethane-α chloralose-anesthetized rats. Intravenous injection of IFN-α (3 × 104 U) also produced a similar excitation of splenic sympathetic nerves. There were no changes in arterial blood pressure and body temperature. The result, together with the previous findings, provides further evidence that the central IFN-α-induced suppression of cytotoxic activity of splenic natural killer cells may be mediated by the sympathetic innervation.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalNeuroscience Letters
Volume125
Issue number1
DOIs
Publication statusPublished - Apr 15 1991

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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