Central administration of L- and D-aspartate attenuates stress behaviors by social isolation and CRF in neonatal chicks

Edi Erwan, Shozo Tomonaga, Junki Yoshida, Mao Nagasawa, Yumi Ogino, D. Michael Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Intracerebroventricular (i.c.v.) administration of L-aspartate (L-Asp) attenuates stress responses in neonatal chicks, but the mechanism has not been clarified. In the present study, three behavioral experiments were carried out under socially isolated stressful conditions exacerbated by the use of corticotrophin-releasing factor (CRF). In Experiment 1, i.c.v. injection of L-Asp attenuated behavioral stress responses (distress vocalization and active wakefulness) in a dose-dependent manner. Furthermore, L-Asp increased time spent standing/sitting motionless with eyes open and sitting motionless with head dropped (sleeping posture) in comparison with the group receiving CRF alone. In Experiment 2, i.c.v. injection of D-Asp dosedependently decreased the number of distress vocalizations and the amount of time spent in active wakefulness. D-Asp increased the time spent standing/sitting motionless with eyes open compared with the group receiving CRF alone. In Experiment 3, we directly compared the effect of L-Asp with that of D-Asp. Both L- and D-Asp induced sedative effects under an acutely stressful condition. However, L-Asp, but not D-Asp, increased the time spent in a sleeping posture. These results indicate that both L- and D-Asp, when present in the brain, could induce a sedative effect, while the mechanism for hypnosis in neonatal chicks may be different for L-Asp in comparison with D-Asp.

Original languageEnglish
Pages (from-to)1969-1976
Number of pages8
JournalAmino Acids
Volume43
Issue number5
DOIs
Publication statusPublished - Nov 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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