Abstract
Carnosine (β-alanyl-L-histidine) is rich in the skeletal muscle and brain, but the function of dipeptides like carnosine in the brain has not been clarified. We previously showed that β-alanyl dipeptides with carboxyl terminal branched chain amino acids induced hyperactivity in chicks when intracerebroventricularly (i.c.v.) administrated. In the present study we investigated the effect of amino terminal histidine related dipeptides under isolation induced stress. I.c.v. injection of L-seryl-L-histidine and L-isoleucyl-L-histidine induced sedation with a weak hypnotic effect, and L-valyl-L-histidine lowered spontaneous activity in chicks. However, L-alanyl-L-histidine, glycyl-L-histidine and L-methionyl-L-histidine had no significant effects in all parameteres determined. These results indicate that L-seryl-L-histidine and L-isoleucyl-L-histidine dipeptides may be effective in improving anxiety and have novel functional effects in the brain.
| Original language | English |
|---|---|
| Pages (from-to) | 65-68 |
| Number of pages | 4 |
| Journal | Letters in Drug Design and Discovery |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2008 |
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All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
Cite this
Central administration of L-Ser-L-His and L-Ile-L-His induced sedative effects under an acute stressful condition in chicks. / Tsuneyoshi, Yousuke; Tomonaga, Shozo; Yamane, Haruka; Morishita, Koji; Denbow, D. Michael; Furuse, Mitsuhiro.
In: Letters in Drug Design and Discovery, Vol. 5, No. 1, 01.01.2008, p. 65-68.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Central administration of L-Ser-L-His and L-Ile-L-His induced sedative effects under an acute stressful condition in chicks
AU - Tsuneyoshi, Yousuke
AU - Tomonaga, Shozo
AU - Yamane, Haruka
AU - Morishita, Koji
AU - Denbow, D. Michael
AU - Furuse, Mitsuhiro
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Carnosine (β-alanyl-L-histidine) is rich in the skeletal muscle and brain, but the function of dipeptides like carnosine in the brain has not been clarified. We previously showed that β-alanyl dipeptides with carboxyl terminal branched chain amino acids induced hyperactivity in chicks when intracerebroventricularly (i.c.v.) administrated. In the present study we investigated the effect of amino terminal histidine related dipeptides under isolation induced stress. I.c.v. injection of L-seryl-L-histidine and L-isoleucyl-L-histidine induced sedation with a weak hypnotic effect, and L-valyl-L-histidine lowered spontaneous activity in chicks. However, L-alanyl-L-histidine, glycyl-L-histidine and L-methionyl-L-histidine had no significant effects in all parameteres determined. These results indicate that L-seryl-L-histidine and L-isoleucyl-L-histidine dipeptides may be effective in improving anxiety and have novel functional effects in the brain.
AB - Carnosine (β-alanyl-L-histidine) is rich in the skeletal muscle and brain, but the function of dipeptides like carnosine in the brain has not been clarified. We previously showed that β-alanyl dipeptides with carboxyl terminal branched chain amino acids induced hyperactivity in chicks when intracerebroventricularly (i.c.v.) administrated. In the present study we investigated the effect of amino terminal histidine related dipeptides under isolation induced stress. I.c.v. injection of L-seryl-L-histidine and L-isoleucyl-L-histidine induced sedation with a weak hypnotic effect, and L-valyl-L-histidine lowered spontaneous activity in chicks. However, L-alanyl-L-histidine, glycyl-L-histidine and L-methionyl-L-histidine had no significant effects in all parameteres determined. These results indicate that L-seryl-L-histidine and L-isoleucyl-L-histidine dipeptides may be effective in improving anxiety and have novel functional effects in the brain.
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UR - http://www.scopus.com/inward/citedby.url?scp=38949168051&partnerID=8YFLogxK
U2 - 10.2174/157018008783406679
DO - 10.2174/157018008783406679
M3 - Article
AN - SCOPUS:38949168051
VL - 5
SP - 65
EP - 68
JO - Letters in Drug Design and Discovery
JF - Letters in Drug Design and Discovery
SN - 1570-1808
IS - 1
ER -