TY - JOUR
T1 - Central administration of neuropeptide Y differentially regulates monoamines and corticosterone in heat-exposed fed and fasted chicks
AU - Bahry, Mohammad A.
AU - Chowdhury, Vishwajit S.
AU - Yang, Hui
AU - Tran, Phuong V.
AU - Do, Phong H.
AU - Han, Guofeng
AU - Ikeda, Hiromi
AU - Cockrem, John F.
AU - Furuse, Mitsuhiro
N1 - Funding Information:
We would like to thank Japan International Cooperation Agency (JICA) and its Project for the Promotion and Enhancement of the Afghan Capacity for Effective Development (PEACE program) for supporting a scholarship to MAB, who came from the Department of Animal Husbandry, Faculty of Agriculture, Balkh University, Mazar-e-Sharif, Afghanistan, to study at Kyushu University. This work was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science [grant number 15K07694] and the Kieikai 2013 and 2014 Research Foundation, Japan to VSC.
PY - 2017/4
Y1 - 2017/4
N2 - Recently, we demonstrated that brain neuropeptide Y (NPY) mRNA expression was increased in heat exposed chicks. However, the functions of brain NPY during heat stress are unknown. This study was conducted to investigate whether centrally administered NPY affects food intake, rectal temperature, monoamines, stress hormones and plasma metabolites in chicks under high ambient temperatures (HT). Five or six-day-old chicks were centrally injected with 0, 188 or 375 pmol of NPY and exposed to either HT (35 ± 1 °C) or a control thermoneutral temperature (CT; 30 ± 1 °C) for 3 h whilst fed or fasted. NPY increased food intake under both CT and HT. NPY reduced rectal temperature 1 and 2 h after central administration under CT, but not under HT. Interestingly, NPY decreased brain serotonin and norepinephrine concentrations in fed chicks, but increased concentrations of brain dopamine and its metabolites in fasted and fed chicks, respectively. Plasma epinephrine was decreased by NPY in fed chicks, but plasma concentrations of norepinephrine and epinephrine were increased significantly by NPY in fasted-heat exposed chicks. Furthermore, NPY significantly reduced plasma corticosterone concentrations in fasted chicks. Plasma glucose and triacylglycerol were increased by NPY in fed chicks, but triacylglycerol declined in fasted NPY-injected chicks. In conclusion, brain NPY may attenuate the reduction of food intake during heat stress and the increased brain NPY might be a potential regulator of the monoamines and corticosterone to modulate stress response in heat-exposed chicks.
AB - Recently, we demonstrated that brain neuropeptide Y (NPY) mRNA expression was increased in heat exposed chicks. However, the functions of brain NPY during heat stress are unknown. This study was conducted to investigate whether centrally administered NPY affects food intake, rectal temperature, monoamines, stress hormones and plasma metabolites in chicks under high ambient temperatures (HT). Five or six-day-old chicks were centrally injected with 0, 188 or 375 pmol of NPY and exposed to either HT (35 ± 1 °C) or a control thermoneutral temperature (CT; 30 ± 1 °C) for 3 h whilst fed or fasted. NPY increased food intake under both CT and HT. NPY reduced rectal temperature 1 and 2 h after central administration under CT, but not under HT. Interestingly, NPY decreased brain serotonin and norepinephrine concentrations in fed chicks, but increased concentrations of brain dopamine and its metabolites in fasted and fed chicks, respectively. Plasma epinephrine was decreased by NPY in fed chicks, but plasma concentrations of norepinephrine and epinephrine were increased significantly by NPY in fasted-heat exposed chicks. Furthermore, NPY significantly reduced plasma corticosterone concentrations in fasted chicks. Plasma glucose and triacylglycerol were increased by NPY in fed chicks, but triacylglycerol declined in fasted NPY-injected chicks. In conclusion, brain NPY may attenuate the reduction of food intake during heat stress and the increased brain NPY might be a potential regulator of the monoamines and corticosterone to modulate stress response in heat-exposed chicks.
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U2 - 10.1016/j.npep.2016.11.008
DO - 10.1016/j.npep.2016.11.008
M3 - Article
C2 - 27979380
AN - SCOPUS:85008180763
VL - 62
SP - 93
EP - 100
JO - Neuropeptides
JF - Neuropeptides
SN - 0143-4179
ER -