Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks

Tomoyuki Koutoku, Hirokazu Takahashi, Shozo Tomonaga, Daichi Oikawa, Shin Saito, Tetsuya Tachibana, Li Han, Kohsuke Hayamizu, D. Michael Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The present study investigated whether centrally administered phosphatidylserine (PS) could modify the behavior of chicks under isolation-induced stress. Isolation stress-induced vocalization and spontaneous activity for 10 min, which were attenuated by intracerebroventricular (i.c.v.) injection of PS. The effect of PS was compared with other phospholipids or l-serine, a constituent of PS. Phosphatidylcholine (PC) had no effect on these behavior, but phosphatidylethanolamine (PE) significantly increased vocalizations and spontaneous activity compared with PS. l-Serine similarly decreased isolation-induced vocalizations and spontaneous activity. To clarify the mechanism by which central PS attenuates isolation-induced stress behavior, the contribution of the acetylcholine (ACh) receptor (AChR) was also investigated. PS was co-injected i.c.v. with the muscarinic AChR (M-AChR) antagonist scopolamine or the nicotinic AChR (N-AChR) antagonist hexamethonium. The suppression of vocalizations and spontaneous activity by PS was partially attenuated by scopolamine, but not hexamethonium. These findings indicate that isolation-induced stress behavior are attenuated by PS, acting partially through the M-AChR.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalNeurochemistry International
Volume47
Issue number3
DOIs
Publication statusPublished - Aug 1 2005

Fingerprint

Phosphatidylserines
Cholinergic Receptors
Hexamethonium
Scopolamine Hydrobromide
Serine
Nicotinic Receptors
Muscarinic Receptors
Phosphatidylcholines
Cholinergic Agents
Phospholipids
Injections

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks. / Koutoku, Tomoyuki; Takahashi, Hirokazu; Tomonaga, Shozo; Oikawa, Daichi; Saito, Shin; Tachibana, Tetsuya; Han, Li; Hayamizu, Kohsuke; Denbow, D. Michael; Furuse, Mitsuhiro.

In: Neurochemistry International, Vol. 47, No. 3, 01.08.2005, p. 183-189.

Research output: Contribution to journalArticle

Koutoku, T, Takahashi, H, Tomonaga, S, Oikawa, D, Saito, S, Tachibana, T, Han, L, Hayamizu, K, Denbow, DM & Furuse, M 2005, 'Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks', Neurochemistry International, vol. 47, no. 3, pp. 183-189. https://doi.org/10.1016/j.neuint.2005.03.006
Koutoku, Tomoyuki ; Takahashi, Hirokazu ; Tomonaga, Shozo ; Oikawa, Daichi ; Saito, Shin ; Tachibana, Tetsuya ; Han, Li ; Hayamizu, Kohsuke ; Denbow, D. Michael ; Furuse, Mitsuhiro. / Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks. In: Neurochemistry International. 2005 ; Vol. 47, No. 3. pp. 183-189.
@article{9d63153e5ccb4e6091d8f0e26aeff566,
title = "Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks",
abstract = "The present study investigated whether centrally administered phosphatidylserine (PS) could modify the behavior of chicks under isolation-induced stress. Isolation stress-induced vocalization and spontaneous activity for 10 min, which were attenuated by intracerebroventricular (i.c.v.) injection of PS. The effect of PS was compared with other phospholipids or l-serine, a constituent of PS. Phosphatidylcholine (PC) had no effect on these behavior, but phosphatidylethanolamine (PE) significantly increased vocalizations and spontaneous activity compared with PS. l-Serine similarly decreased isolation-induced vocalizations and spontaneous activity. To clarify the mechanism by which central PS attenuates isolation-induced stress behavior, the contribution of the acetylcholine (ACh) receptor (AChR) was also investigated. PS was co-injected i.c.v. with the muscarinic AChR (M-AChR) antagonist scopolamine or the nicotinic AChR (N-AChR) antagonist hexamethonium. The suppression of vocalizations and spontaneous activity by PS was partially attenuated by scopolamine, but not hexamethonium. These findings indicate that isolation-induced stress behavior are attenuated by PS, acting partially through the M-AChR.",
author = "Tomoyuki Koutoku and Hirokazu Takahashi and Shozo Tomonaga and Daichi Oikawa and Shin Saito and Tetsuya Tachibana and Li Han and Kohsuke Hayamizu and Denbow, {D. Michael} and Mitsuhiro Furuse",
year = "2005",
month = "8",
day = "1",
doi = "10.1016/j.neuint.2005.03.006",
language = "English",
volume = "47",
pages = "183--189",
journal = "Neurochemistry International",
issn = "0197-0186",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks

AU - Koutoku, Tomoyuki

AU - Takahashi, Hirokazu

AU - Tomonaga, Shozo

AU - Oikawa, Daichi

AU - Saito, Shin

AU - Tachibana, Tetsuya

AU - Han, Li

AU - Hayamizu, Kohsuke

AU - Denbow, D. Michael

AU - Furuse, Mitsuhiro

PY - 2005/8/1

Y1 - 2005/8/1

N2 - The present study investigated whether centrally administered phosphatidylserine (PS) could modify the behavior of chicks under isolation-induced stress. Isolation stress-induced vocalization and spontaneous activity for 10 min, which were attenuated by intracerebroventricular (i.c.v.) injection of PS. The effect of PS was compared with other phospholipids or l-serine, a constituent of PS. Phosphatidylcholine (PC) had no effect on these behavior, but phosphatidylethanolamine (PE) significantly increased vocalizations and spontaneous activity compared with PS. l-Serine similarly decreased isolation-induced vocalizations and spontaneous activity. To clarify the mechanism by which central PS attenuates isolation-induced stress behavior, the contribution of the acetylcholine (ACh) receptor (AChR) was also investigated. PS was co-injected i.c.v. with the muscarinic AChR (M-AChR) antagonist scopolamine or the nicotinic AChR (N-AChR) antagonist hexamethonium. The suppression of vocalizations and spontaneous activity by PS was partially attenuated by scopolamine, but not hexamethonium. These findings indicate that isolation-induced stress behavior are attenuated by PS, acting partially through the M-AChR.

AB - The present study investigated whether centrally administered phosphatidylserine (PS) could modify the behavior of chicks under isolation-induced stress. Isolation stress-induced vocalization and spontaneous activity for 10 min, which were attenuated by intracerebroventricular (i.c.v.) injection of PS. The effect of PS was compared with other phospholipids or l-serine, a constituent of PS. Phosphatidylcholine (PC) had no effect on these behavior, but phosphatidylethanolamine (PE) significantly increased vocalizations and spontaneous activity compared with PS. l-Serine similarly decreased isolation-induced vocalizations and spontaneous activity. To clarify the mechanism by which central PS attenuates isolation-induced stress behavior, the contribution of the acetylcholine (ACh) receptor (AChR) was also investigated. PS was co-injected i.c.v. with the muscarinic AChR (M-AChR) antagonist scopolamine or the nicotinic AChR (N-AChR) antagonist hexamethonium. The suppression of vocalizations and spontaneous activity by PS was partially attenuated by scopolamine, but not hexamethonium. These findings indicate that isolation-induced stress behavior are attenuated by PS, acting partially through the M-AChR.

UR - http://www.scopus.com/inward/record.url?scp=20544462766&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20544462766&partnerID=8YFLogxK

U2 - 10.1016/j.neuint.2005.03.006

DO - 10.1016/j.neuint.2005.03.006

M3 - Article

VL - 47

SP - 183

EP - 189

JO - Neurochemistry International

JF - Neurochemistry International

SN - 0197-0186

IS - 3

ER -