Central adrenomedullin augments the baroreceptor reflex in conscious rabbits

Kiyoshi Matsumura, Isao Abe, Takuya Tsuchihashi, Masatoshi Fujishima

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We examined the roles of central adrenomedullin, proadrenomedullin N- terminal 20 peptide (PAMP), and calcitonin gene-related peptide (CGRP) on the baroreceptor reflex in conscious rabbits. Intracerebroventricular injection of adrenomedullin (0.2 and 1 nmol/80 μL) elicited dose-related increases in arterial pressure and renal sympathetic nerve activity. On the other hand, a subpressor dose of intracerebroventricular infusion of adrenomedullin (1 nmol/300 μL per hour) caused significant increases in baroreflex sensitivities assessed by renal sympathetic nerve activity and heart rate compared with vehicle infusion (G(max); -14.9±1.7 versus -8.0±0.7%/mm Hg, P<0.01, and -8.1±0.8 versus -5.1±0.5 bpm/mm Hg, P<0.01, respectively). Intracerebroventricular infusion of CGRP (1 nmol/300 μL per hour), which is structurally homologous to adrenomedullin, also enhanced the baroreflex controls of renal sympathetic nerve activity and heart rate. However, the intracerebroventricular infusion of PAMP (30 nmol/300 μL per hour) failed to alter the baseline levels of arterial pressure and baroreflex sensitivities. These results suggest that central adrenomedullin and CGRP, but not PAMP, participate in cardiovascular regulation to augment the baroreflex controls of renal sympathetic nerve activity and heart rate in conscious rabbits.

Original languageEnglish
Pages (from-to)992-997
Number of pages6
JournalHypertension
Volume33
Issue number4
DOIs
Publication statusPublished - Apr 1999

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Adrenomedullin
Baroreflex
Intraventricular Infusions
Rabbits
Calcitonin Gene-Related Peptide
Kidney
Heart Rate
Arterial Pressure
Injections
Pathogen-Associated Molecular Pattern Molecules

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Matsumura, K., Abe, I., Tsuchihashi, T., & Fujishima, M. (1999). Central adrenomedullin augments the baroreceptor reflex in conscious rabbits. Hypertension, 33(4), 992-997. https://doi.org/10.1161/01.HYP.33.4.992

Central adrenomedullin augments the baroreceptor reflex in conscious rabbits. / Matsumura, Kiyoshi; Abe, Isao; Tsuchihashi, Takuya; Fujishima, Masatoshi.

In: Hypertension, Vol. 33, No. 4, 04.1999, p. 992-997.

Research output: Contribution to journalArticle

Matsumura, K, Abe, I, Tsuchihashi, T & Fujishima, M 1999, 'Central adrenomedullin augments the baroreceptor reflex in conscious rabbits', Hypertension, vol. 33, no. 4, pp. 992-997. https://doi.org/10.1161/01.HYP.33.4.992
Matsumura, Kiyoshi ; Abe, Isao ; Tsuchihashi, Takuya ; Fujishima, Masatoshi. / Central adrenomedullin augments the baroreceptor reflex in conscious rabbits. In: Hypertension. 1999 ; Vol. 33, No. 4. pp. 992-997.
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